肿瘤微环境pH响应靶向载体设计研究进展  

Recent progress of design targeted vector pH responsive to tumor microenvironment

作　　者：臧新龙 赵秀峰[2] 陈大为[1] 赵秀丽[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]牡丹江医学院红旗医院,黑龙江牡丹江157011

出　　处：《沈阳药科大学学报》2014年第7期575-583,共9页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(81202483)

摘　　要：目的归纳和概括基于肿瘤微环境pH响应载体设计的方法与策略。方法以国内外具有代表性文献34篇为依据,对pH敏感靶向传递系统的设计原理方法进行分析、整理和归纳。结果 pH敏感靶向载体借助于其pH敏感基团对肿瘤微环境做出响应,可以实现药物的定向递送,杀死肿瘤细胞并降低药物对正常组织的毒副作用。结论构建pH敏感载体用作肿瘤的靶向治疗,具有重要的研究意义。Objective To review the methods on the construction of pH-sensitive vector responsive to tumor microenvironment.Methods Based on the representative references,the principles to design pH-sensitive targeted drug delivery systems were summarized.Results Through pH-sensitive groups,the vectors responding to tumor microenvironment deliver drugs to tumor cells and decrease the toxicity to normal tissue.Conclusions It’s significant to construct pH-sensitive vector for tumor therapy.

关 键 词：肿瘤微环境 PH敏感 载体设计 肿瘤靶向治疗 

分 类 号：R94[医药卫生—药剂学]