糖尿病患者C-肽、空腹血糖、糖化血清蛋白和糖化血红蛋白的相关性分析  

Correlation of C-Peptide,Fasting Blood Glucose,Glycosylated Serum Protein and Glycosylated Hemoglobin of Diabetics

作　　者：张萍[1] 彭俊华[1] 杨迎桂[1] 杨志华[1] 冯小明[1] 

机构地区：[1]兰州军区兰州总医院检验科,甘肃兰州730050

出　　处：《甘肃科学学报》2014年第4期58-60,共3页Journal of Gansu Sciences

摘　　要：分析糖尿病患者中C-肽、空腹血糖(FBG)、糖化血清蛋白(GSP)及糖化血红蛋白(HbA1c)水平的相关性.收集糖尿病患者及查体健康人群的血,用化学发光分析法检测C-肽和胰岛素水平,用高效液相层析法检测HbA1c,用生化仪检测FBG和GSP.结果显示糖尿病患者血中C-肽值和胰岛素水平分别为(320.6±103.6)pmol/L、(5.18±1.39)mU/L,分别明显低于健康人群(P<0.05);但血中FBG、GSP、HbA1c水平分别为(9.69±2.14)mmol/L、(8.27±1.53)%、(3.75±0.64)mmol/L,分别明显高于健康人群(P<0.05).C-肽与FBG呈负相关(r=-0.565,P<0.01);HbA1c与GSP呈正相关(r=0.523,P<0.01).结果提示联合检测C-肽、FBG、HbA1c及GSP,能更准确反映患者血糖的控制水平,提高糖尿病的诊疗水平.The correlation of C-peptid, fasting blood glucose （FBG）, glycosylated serum protein （GSP） and glycosylated hemoglobin （HbAle） of diabetics was analyzed. The level of C-peptide and that of insulin in blood from diabetics and healthy people were detected by chemiluminescence,the level of HbAlc were examined by high performance liquid chromatography,and the level of FBG and GSP was analyzed on the automatic biochemical analyzer. The results showed that the level of C-peptid and that of insulin of diabetics were respectively （320.6±103.6） pmol/L and （5.18±1.39） mU/L,significantly lower than those of healthy people （P〈0.05）. The level of FBG,that of GSP and that of HbAlc were respectively （9.69± 2.14）,mmol/L,（8.27±1.53） % and （3.75±0. 64） mmol/L,significantly higher than those of healthy people （P〈0.05）. There were a negative correlation of C-peptide with FBG （r=-0. 565,P〈0.01） and a positive correlation of HbAlc with GSP （r=0. 523 ,P〈0.01）. The results suggested that the combined detection of C-peptide, FBG, HbAlc and GSP reflected the level of blood sugar more accurately and improved the diagnosis and treatment of diabetes.

关 键 词：糖尿病 C肽 糖化血红蛋白 糖化血清蛋白 

分 类 号：R587.1[医药卫生—内分泌]