甲泼尼龙联合环磷酰胺冲击治疗儿童难治性肾病综合征的临床效果观察  

Clinical observation of methylprednisolone and cyclophosphamide pulse therapy in children with refractory nephrotic syndrome

作　　者：曾海江[1] 李静[2] 黄郁波[1] 

机构地区：[1]江西省赣州市人民医院儿科,江西赣州341000 [2]赣南医学院第一附属医院儿科,江西赣州341000

出　　处：《中国当代医药》2014年第21期82-83,86,共3页China Modern Medicine

摘　　要：目的探讨甲泼尼龙联合环磷酰胺冲击治疗儿童难治性肾病综合征的临床效果。方法选择本院2011年1月～2013年12月收治的58例难治性肾病综合征患儿，随机分为两组，治疗组采用甲泼尼龙联合环磷酰胺冲击治疗。对照组采用泼尼松联合环磷酰胺冲击治疗，8周后观察两组患儿的疗效和不良反应情况。结果治疗组的总有效率为86．2％，明显高于对照组的55．2％，两组差异有统计学意义（P〈0．05）；治疗组中有5例发生不同程度的白细胞减少、胃肠道反应、血压升高等不良反应，不良反应发生率为17．2％，对照组中有10例发生不同程度的白细胞减少、胃肠道反应、血压升高等不良反应，不良反应发生率为34．5％，两组差异有统计学意义（P〈0．05）。结论甲泼尼龙联合环磷酰胺冲击治疗儿童难治性肾病综合征的临床效果显著，且安全性高、毒副作用小，值得临床推广使用。Objective To explore the clinical effect of methylprednisolone and cyclophosphamide pulse therapy in children with refractory nephrotic syndrome. Methods 58 patients with refractory nephrotic syndrome were selected in our hospital from January 2011 to December 2013,and they were randomly divided into two groups,the treatment group patients were treated with methylprednisolone and cyelophosphamide pulse,the control group patients were treated with prednisone and cyclophosphamide pulse,the effect and adverse reaction of two groups of children after 8 weeks were observed. Results The total effective rate was 86.2% in the treatment group,significantly higher than 55.2% of the control group,there were statistical significance between the two groups （P〈0.05）.5 cases in the treatment group of white cell occurred different reduction,adverse reaction of gastrointestinal tract reaction and elevated blood pressure,the incidence rate of adverse reaction in control group was 17.2%.10 cases in the control group of white cell occurred different degrees of reduction,adverse reaction of gastrointestinal tract reaction and elevated blood pressure,the adverse reaction rate was 34.5%,with statistical significance between the two groups （P〈0.05）. Conclusion The curative effect of methylprednisolone and cyclophosphamide pulse therapy in children with refractory nephrotic syndrome is significantly,and high safety,little side effect,and is worthy of clinical use.

关 键 词：甲泼尼龙 环磷酰胺 冲击治疗 儿童 难治性肾病综合征 

分 类 号：R726.9[医药卫生—儿科]