纳洛酮与醒脑静联合抢救COPD并Ⅱ型呼吸衰竭的临床观察  

Clinical observation of joint naloxone-Xingnaojing in rescue of COPD with type II respiratory failure

作　　者：李姗 王嫚[2] 胡东辉 

机构地区：[1]湖北省武汉市中山医院急诊科,湖北武汉430033 [2]华中科技大学同济医学院,湖北武汉430030 [3]湖北省中山医院肝病科,湖北武汉430033

出　　处：《现代预防医学》2014年第15期2761-2763,共3页Modern Preventive Medicine

基　　金：武汉市卫生局重点医学联合攻关项目(0613)

摘　　要：目的探讨纳洛酮与醒脑静联合抢救慢性阻塞性肺部疾病(COPD)并Ⅱ型呼吸衰竭的临床观察。方法将314例COPD并Ⅱ型呼吸衰竭患者随机分为两组,治疗组与对照组。治疗组162例,用纳洛酮联合醒脑静治疗,对照组152例用常规方法治疗。结果治疗组总有效率为96.3%,对照组总有效率为94.1%,两组差异有统计学意义(P<0.05)。动脉血气分析结果表明动脉血氧分压(PaO2)在干预后,治疗组的结果明显高于对照组,差异有统计学意义(P<0.05),而动脉血二氧化碳分压(PaCO2)的情况低于对照组,但差异无统计学意义(P>0.05)。结论纳洛酮与醒脑静联合治疗性阻塞性肺气肿并Ⅱ型呼吸衰竭临床疗效确切。Objective To investigate joint naloxone with Xingnaojing in rescue of chronic obstructive pulmonary disease （COPD） and type Ⅱ respiratory failure. Methods 314 patients with COPD and type Ⅱ respiratory failure were randomly divided into two groups, the treatment group and the control group. 162 cases of the treatment group, naloxone and Xingnaojing as treatment, control group of 152 cases treated by conventional methods. Results In the treatment group, the total effective rate was 96.3%, compared with the control group （94.1%）, there were significant differences（P〈0.05）. Blood gas analysis showed： after the intervention of arterial partial pressure of oxygen （PaO2）, the results in the treatment group were significantly higher than in the control group （P〈0.05）, arterial partial pressure of carbon dioxide （PaCO2） was slightly lower than in the control group and without significant differences （P〉0.05）. Conclusion Naloxone and Xingnaojing combined therapy in treatment of obstructive emphysema and type Ⅱ respiratory failure has an obvious clinical efficacy.

关 键 词：纳洛酮 醒脑静 Ⅱ型呼吸衰竭 临床观察 

分 类 号：R4[医药卫生—临床医学]