安徽某市吸毒人群HEV感染的现况调查分析  

Survey on hepatitis E virus infection among drug abuse user in a city of Anhui province

作　　者：朱明[1] 程险峰[1] 文育锋[2] 韩凌飞 张振[1] 詹圣伟[1] 郑锦绣[1] 

机构地区：[1]马鞍山市疾病预防控制中心,安徽马鞍山243000 [2]皖南医学院,安徽芜湖241002 [3]马鞍山市医疗集团临床检验中心,安徽马鞍山243000

出　　处：《现代预防医学》2014年第15期2837-2840,共4页Modern Preventive Medicine

基　　金：安徽省卫生厅项目(2011Y0104);皖南医学院重点科研项目培育基金(WK2012Z02)

摘　　要：目的了解吸毒人群戊型肝炎病毒(HEV)感染情况,分析此人群高危行为方式与HEV感染之间的联系,为预防和控制戊型肝炎提供依据。方法采用横断面研究,从戒毒所和美沙酮门诊选择379名吸毒者,调查其吸毒行为方式、性行为特点,用ELISA法检测HEV-IgG抗体,分析吸毒人群戊型肝炎感染的影响因素。结果调查人群静脉注射吸毒的比例为52.8%,吸毒人群戊肝感染率为8.4%,40岁以上年龄组人群HEV感染率为16.3%,高于其他年龄组感染率(χ2=10.580,P=0.005);吸食海洛因的人群HEV感染率为12.0%,高于吸食冰毒人群的3.4%和吸食其他毒品人群的6.3%,差异有统计学意义(χ2=8.542,P=0.014);静脉吸毒人群的感染率为12.5%,高于非静脉吸毒人群的3.9%,差异有统计学意义(χ2=9.015,P=0.003)。结论静脉注射吸毒和年龄因素可能是吸毒人群HEV高感染的重要因素。Objective To investigate the prevalence hepatitis E virus （HEV） infection among drug abuse users （DUS）, analyze the relation between high-risk behaviors and HEV infection, and provide the strategies for prevention of hepatitis E （HE）. Methods A cross-sectional study was conducted and 379 DUS were enrolled from the drug rehabilitation center and methadone maintenance treatment clinic. The questionnaire included the drug using behaviors, the sexual behaviors among DUS. The HEV antibodies were tested with enzyme linked immunosorbent assay （ELISA）. And the impact factors of the HEV infection were analyzed. Results 52.8% participants were drug users by injection. The positive rate of HEV antibodies of DUS was 8.4%. The HEV infection rate in the group of 40-years was 16.3%, and it was significantly higher than that of others group （χ^2=10.580, P=0.005）. The positive rate of HEV antibodies in heroin abuse group （12.0%） was significantly higher than that the methamphetamine group 0.4%） and other drug using group （6.3%） （χ^2=8.542, P=0.014）. The rate of HEV infection of intravenous drug users （12.5%） was significantly higher than that of non-intravenous drug users （3.9%） （χ^2=9.015,P=0.003）. No significant association was found between HEV infection and sexual behavior. Conclusion Intravenous injection and age may be the risk factors of HEV infection among DUS.

关 键 词：戊型肝炎 戊型肝炎病毒 静脉注射吸毒 性行为 吸毒人群 

分 类 号：R195[医药卫生—卫生统计学]