不同频率谐振致腰椎间盘组织病理学变化的实验研究  

Vibration at different frequencies inducing histopathological changes of intervertebral discs:Experimental study

作　　者：常祺[1] 王帅[1] 任洪峰[1] 陈国立[1] 朱履刚[1] 郭延岭[1] 周阳[1] 黄昌林[1] 

机构地区：[1]解放军150医院骨科/全军军事训练医学研究所,河南洛阳471031

出　　处：《实用医药杂志》2014年第7期620-622,共3页Practical Journal of Medicine & Pharmacy

基　　金：2014总后勤部卫生重大专项(2014ZX09J14101-01A)

摘　　要：目的：观察坐位下不同频率谐振对兔腰椎间盘组织病理学影响，探讨振动引起腰椎间盘病理学改变的机制。方法取90只成年健康的日本大耳白兔，随机分为5组，每组18只。 A组为正常对照组；B为造模对照组；C为4 Hz振动组；D为5 Hz振动组；E为6 Hz振动组。分别于实验第2、4、6周每组随机抽取6只白兔，取其腰5～6椎间盘组织，观察其组织形态学变化，并进行病理学评分。结果振动组整体髓核组织形态改变相对较造模对照组出现早，振动6 Hz组椎间盘组织病理学评分显著高于其他组别（P＜0．05），且随时间延长逐渐升高；振动4 Hz组与造模对照组相比无显著变化。结论振动产生动态应力易导致髓核组织病变，产生共振效应时可使椎间盘组织产生的病变程度最大。Objective To analyze the effect of different frequency of vibration at constrained body posture on histomorphology of rabbit intervertebral discs,and to investigate the mechanism of vibration with different frequency effecting on the rabbit intervertebral discs. Methods Ninety healthy rabbits were randomly divided into 5 groups （n=18）：Groups A as normal group;Groups B as control group;Groups C as 4 Hz vibration group;Groups D as 5 Hz vibration group; Groups E as 6 Hz vibration group. The L5/L6 intervertebral discs of six rabbits were extractioned on the 2nd,4th,8th week in each group randomly.Changes of intervertebral discs in histomorphology were observed at different time points,and their pathological grades were recorded. Results Pathological changes of nucleus pulposus in vibration groups were earlier than that in normal and control group , and the pathological grade in 6 Hz vibration group was obviously higher than that in other groups （P＆lt;0.05）,which advanced with time. There were no significant difference between 4 Hz vibration group and control group in pathology of nucleus pulposus. Conclusion Dynamic stress caused by vibration can easily induce the harmful pathological changes of nucleus pulposus,and appearance of resonance effect will lead to a more grave destroy.

关 键 词：振动频率 兔 腰椎间盘 谐振 组织形态学 髓核 椎间盘源性低位背痛 病理学 

分 类 号：R681.53[医药卫生—骨科学]