心脑宁片对结扎冠状动脉所致大鼠心肌缺血模型的影响  

Effect of Xinnaoning Tablets on Myocardial Ischemia Rat Model Induced by Coronary Artery Ligation

作　　者：吕宏迪[1] 郝少君[1] 王希东[1] 李文俊[1] 张正臣[1] 

机构地区：[1]解放军第371中心医院,河南新乡453000

出　　处：《中国药师》2014年第7期1073-1075,共3页China Pharmacist

基　　金：河南省科学技术厅2009年科技发展计划(编号:092102310202)

摘　　要：目的:观察心脑宁片对结扎冠状动脉所致大鼠心肌缺血模型的影响。方法:大鼠70只,分为7组,分别为空白对照组,模型组,硝苯地平组,脑心通组,心脑宁高、中、低剂量组,各组分别灌服相应药物,每天给药1次,连续7 d;于最后1次给药后结扎冠状动脉左前降支(LAD),造大鼠心肌缺血模型。缺血2 h后,腹主动脉取血,测血清CK、LDH、MDA、SOD水平;处死大鼠,取心脏,10%甲醛固定,HE染色、切片。结果:与模型组比,心脑宁片组可显著降低血CK、LDH、MDA水平(P<0.01),可显著升高血SOD活力(P<0.01),可显著降低减轻缺血所致心肌的损伤(P<0.01)。结论:心脑宁片对结扎冠状动脉所致大鼠心肌缺血有好的改善作用。Objective：To observe the effect of Xinnaoning tablets on myocardial ischemia rat model induced by coronary artery ligation.Methods：Totally 70 rats were divided into 7 groups,including the blank control group,model group,nifedipine group,Naoxintong group,Xinnaoning group respectively with high,medium and low dosage.The dosage regimen was one time per day for 7 days.After the last administration,the left anterior descending （LAD） of coronary artery was ligatured to make the myocardial ischemia rat model.After 2 hours of the ligation,blood from abdominal aorta was collected and then the level of CK,LDH,MDA and SOD was assayed.Then the rats were sacrificed,the heart was withdrawn,fixed by 10％ formalin,stained by HE and cut into slices.Results：Compared with the model group,Xinnaoning tablets could reduce the level of CK,LDH and MDA significantly （P ＜ 0.01）,increase the level of SOD significantly （P ＜ 0.01）,and reduce myocardial injury induced by ischemia significantly （P ＜ 0.01）.Condusion：Xinnaoning tablets have good effect on myocardial ischemia rat model induced by coronary artery ligation.

关 键 词：心脑宁片 大鼠 结扎冠状动脉 心肌缺血模型 脑心通胶囊 硝苯地平片 

分 类 号：R285.5[医药卫生—中药学]