DAZL基因与男性不育关系的研究进展  

DAZL and male infertility: An update

作　　者：徐爱明[1] 刘边疆[1] 王增军[1] 

机构地区：[1]南京医科大学第一附属医院泌尿外科,江苏南京210029

出　　处：《中华男科学杂志》2014年第7期647-650,共4页National Journal of Andrology

基　　金：国家自然科学基金(81200467;30872575)~~

摘　　要：DAZL基因为DAZ基因家族成员之一,在人类精子发生的过程中,DAZL基因发挥着至关重要的调控作用。基因DAZL通过其表观遗传学修饰作用,主要是DAZ的甲基化,调控基因启动子来实现DAZL基因在生殖细胞中的表达。DAZL基因多态性位点分析(SNP)与男性不育依旧是一个值得探讨的研究方向,目前认为与地域和种族有关。本文通过总结近来的相关研究资料,阐述精子发生过程中的DAZL基因甲基化状态的改变以及DAZL的SNPs与男性不育之间的联系,为男性不育的治疗提供新的理论基础和临床思路。DAZL, a member of the DAZ family, plays a key role in human spermatogenesis. It regulates the promoter via genetic modification, especially DNA methylation, promoting the transcription of DAZL. Besides, the relation of DAZL SNPs with male infertility has been a hot spot of research for many years. It is deduced that local and ethnic factors may be associated with the failure of spermatogenesis. This article presents an overview on the results of recent studies, changes in the DNA methylation of DAZL in spermatogenesis, and the association of DAZL SNPs with male infertility, aiming to provide a new theoretical basis and clinical strategy for the treatment of male infertility.

关 键 词：DAZL基因 甲基化 单核苷酸多态性 男性不育 

分 类 号：R698.2[医药卫生—泌尿科学]