TNF-α-308G/A基因多态性与慢性牙周炎易感性关系的Meta分析  

TNF-α-308 G/A gene polymorphism and risk of chronic periodontitis:a Meta analysis

作　　者：钱利菊 熊亚林[1] 刘琴[2] 秦朴[1] 杜跃华[1] 

机构地区：[1]重庆医科大学附属口腔医院正畸科、重庆市口腔疾病与生物医学研究中心,重庆400015 [2]重庆医科大学公共卫生与管理学院妇幼保健与儿童少年卫生学教研室,重庆400016

出　　处：《重庆医科大学学报》2014年第6期864-869,共6页Journal of Chongqing Medical University

基　　金：重庆市卫生局资助项目(编号:2012-1-055)

摘　　要：目的：探讨肿瘤坏死因子-α-308（tumor necrosis factor-alpha-308,TNF-α-308）基因多态性与慢性牙周炎（chronic periodontitis,CP）易感性的关系。方法：计算机检索PubMed、EMbase、CNKI、CBM、VIP和万方数据,检索时限均为建库至2013年10月。按照纳入与排除标准筛出关于TNF-α-308G/A基因多态性与CP易感性相关的病例-对照研究或队列研究。对纳入研究采用Newcastle-Ottawa量表进行质量评价。采用RevMan 5.2.0和Stata 12.0软件进行统计分析。结果：共纳入18个研究,1 420例CP患者,1 538例健康对照。Meta分析结果显示：①TNF-α-308G/A基因多态性与CP相关性：等位基因遗传模型A vs.G（OR=1.05,95%CI=0.83~1.34,P=0.68）、加性遗传模型AA vs.GG（OR=1.35,95%CI=0.78~2.34,P=0.28）、显性遗传模型AA＋AG vs.GG（OR=1.02,95%CI=0.79~1.33,P=0.88）、隐性遗传模型AA vs.AG＋GG（OR=1.42,95%CI=0.82~2.45,P=0.21）;②以人种、严重程度、吸烟情况为亚组进行分层分析,结果显示TNF-α-308位点的多样性在不同人群中也无明显相关性（P〉0.05）。结论：现有证据显示,TNF-α-308基因多态性可能与CP易感性无关。由于纳入研究数量有限,上述结论尚需开展更多高质量、大样本的随机对照试验加以验证。Objective：To evaluate the association between TNF-α-308 G/A gene polymorphism and the risk of chronic periodontitis（CP）. Methods：A Meta analysis was performed to analyze the association between TNF-α-308 gene polymorphism and the risk of CP. Studies on correlation between TNF-α-308 G/A gene polymorphism and susceptibility to CP were systematically retrieved from PubMed,Embase,CNKI,CBM,VIP and WanFang Data. Academic level of studies included in this article was assessed according to the Newcastle-Ottawa Scale（NOS）. Meta analysis was carried out using the Review Manager（version 5.2.0）and Stata（version 12.0）.Results：A total of 18 case-control studies（1 420 cases,1 538 controls）were included in this Meta analysis. The results showed no statistically significant difference in all genotype models between CP cases and controls：allele genetic model A vs. G（OR=1.05,95%CI=0.83 to 1.34,P=0.68）,additive genetic model AA vs. GG（OR=1.35,95%CI=0.78 to 2.34,P=0.28）,dominant model AA＋AG vs. GG（OR=1.02,95%CI=0.79 to 1.33,P=0.88）,recessive model AA vs. AG＋GG（OR=1.42,95%CI=0.82 to 2.45,P=0.21）. In the subgroup analysis by ethnicity,severity and smoking status,no statistically differences was found between CP cases and controls（P ＆gt;0.05）.Conclusion：TNF-α-308G/A gene polymorphism may not be a risk factor of CP. Due to the limited quantity of the included studies;further studies are needed to validate the above conclusion.

关 键 词：慢性牙周炎 肿瘤坏死因子-Α 多态性 META分析 

分 类 号：R285.5[医药卫生—中药学]