冻融胚胎移植3种内膜准备方案成功妊娠者的临床比较  

Clinical Comparison among Successful Pregnant Patients with Three Different Therapies in Frozen-thawed Embryo Transfer Cycles

作　　者：刘美[1] 江胜芳[1] 胡玥玥[1] 张颖[1] 张昌军[1] 

机构地区：[1]湖北医药学院附属人民医院生殖医学中心,十堰442000

出　　处：《生殖与避孕》2014年第7期538-542,共5页Reproduction and Contraception

摘　　要：目的:探讨冻融胚胎移植(FET)3种内膜准备方案成功妊娠者的临床特征。方法:回顾性分析188个FET周期,其中98个成功妊娠,比较自然周期(A组,n=42)、激素替代周期(B组,n=46)和促排卵周期(C组,n=10)这3种方案成功妊娠者在年龄、移植日及移植第4日血清激素水平、移植胚胎数、I级胚胎比例、移植位置和黄体酮的用量的影响上是否存在差异。结果:1 B组移植日、移植第4日血清E2水平、E2/P值、黄体酮的用量均明显高于A组,而P水平明显低于A组,差异均有统计学意义(P<0.05);年龄、移植胚胎数、I级胚胎比例及移植位置上A、B无统计学差异(P>0.05)。2 C组可移植胚胎数明显少于A组和B组,差异均有统计学意义(P<0.05);而在年龄、移植日及移植第4日血清激素水平、I级胚胎比例、移植位置和黄体酮的用量与A组和B组间无统计学差异(P>0.05)。结论:B组方案者黄体支持时黄体酮的用量应高于A组,B组方案在移植日及移植第4日孕酮值低于A组,但并不影响妊娠,C组方案者可移植胚胎数减少可能并不影响妊娠率。Objective： To explore the clinical characteristics of successful pregnant patient with different therapy in frozen-thawed embryo transfer （FET） cycles. Methods： A total of 188 FET cycles were retrospectively analyzed. Among them, 98 cycles got successfully pregant, the differences of successful pregnant patients＇ age, the concentration of serum hormone on the 1 st and 4th day of embryo transfer （ET）, the amount of transplanting embryos, the rate of best embryo, the location of embryo and the dose of progesterone used were compared when they were treated by natural cycle （group A, n=42）, hormone replacing cycles （group B, n=46）or superovulation treatment （group C, n=10）. Results： 1） Compared with group A the patients in group B had a higher concentration of serum E2, E2/P on the 1st and 4th day of embryo transfer, and lower dose of progesterone on the 1 st and 4th day of embryo transfer, and they used higher dose of progesterone. There were no significant differences in age, the amount of transplanting embryos, the rate of transferrable embryos and the location of embryo. 2） Compared with group A and group B respectively, the patients in group C had lower amount of transferrable embryos, and there were no significant differences in the age of the patient, the concen- tration of serum hormone on the 1 st and 4th day of embryo transfer, the rate of grade I embryos, the location of embryo transplanted and the dose of progesterone. Conclusion： Compared with group A, the patients in group B should be given larger dose of progesterone, and the concentration of serum progesterone on the 1 st and 4th day of embryo transfer was lower which had no impact on pregnancy. For the treatment of superovulation, the reduce of the number of embryo transferrable also has no influence on pregnancy rate.

关 键 词：冻融胚胎移植(FET) 内膜准备方案 成功妊娠 

分 类 号：R714.8[医药卫生—妇产科学]