子宫内膜自然杀伤细胞与妊娠关系的研究进展  

Progression of Uterine Natural Killer Cells and Pregnancy

作　　者：季晓微[1] 孙赟[1,2] 

机构地区：[1]上海交通大学医学院附属仁济医院生殖医学科,上海200001 [2]上海市辅助生殖与优生重点实验室,上海200135

出　　处：《生殖与避孕》2014年第7期556-559,575,共5页Reproduction and Contraception

基　　金：上海市科委基础研究重点项目(编号12JC1405800);上海市科委引导项目(编号114119a1900)

摘　　要：子宫内膜自然杀伤(uNK)细胞是胚胎植入前内膜和早孕期蜕膜中数量最多的一类免疫细胞。母体的uNK细胞与胎儿的滋养层细胞相邻且相互作用。uNK细胞分泌一系列细胞因子和血管生长因子,调控滋养层细胞入侵并参与子宫螺旋动脉的重塑。uNK细胞数量的增多与反复种植失败(RIF)、复发性流产(RSA)有关。但仍需更多的研究阐明uNK细胞在胚胎种植过程中的具体作用、对内膜容受性的影响,以此作为临床治疗的依据。Uterine natural killer （uNK） cells are the most abundant immune cells in preimplantation endometrium and early pregnancy deciduas. Maternal uNK cells are adjacent to, and have the ability to interact directly with fetal trophoblasts, uNK cells can secrete an array of cytokines and angiogenesis factors that are important in regulation of trophoblast invasion and involved in remodeling of uterine spiral arteries. The increased number of uNK cells is associated with recurrent implantation failure and recurrent spontaneous abortion （RSA）. More work needs to be done to establish a specific role for uNK cells in the process of embryo implantation and effect on endometrial receptivity and to use uNK cells as the basis for clinical treatment.

关 键 词：子宫内膜自然杀伤(uNK)细胞 反复种植失败(RIF) 复发性流产(RSA) 

分 类 号：R714[医药卫生—妇产科学]