有生育需求中老年男性精子参数的评价  

Evaluation on Sperm Parameters from Semen of Men Aged 50-58 Years Who Wanted to be Father

作　　者：徐谊朝[1] 朱伟杰[2] 李菁[3] 梁蔚波[1] 江欢[2] 

机构地区：[1]暨南大学附属第一医院泌尿外科,广州510630 [2]暨南大学生命科学技术学院,广州510632 [3]暨南大学医学院,广州510632

出　　处：《生殖与避孕》2014年第7期599-602,共4页Reproduction and Contraception

摘　　要：目的：评价有生育需求中老年男性精子参数的变化。方法：42例50~58岁有生育需求男性的精液标本,按照其既往生育史分组,A组：继发性不育23例,平均年龄52.9±2.2（50~58）岁;B组：原发性不育19例,平均年龄52.7±2.7（50~58）岁。按世界卫生组织手册（WHO,2010）方法,检测患者的精子活动率、前向运动精子率、精子浓度、精子畸形率、畸形精子指数和精子顶体完整率。结果：A组的畸形精子率显著低于B组（P0.05）。与WHO手册（2010）的参考值对照,A、B组的精子活动率均数、前向运动精子率均数和B组的正常形态精子率均数低于参考值下限。A组和B组分别有11例（47.8%）、5例（26.3%）的精子活动率、前向运动精子率、精子浓度和正常形态精子率达到WHO的参考值范围,但达到WHO参考值的例数比率组间无统计学差异（P〉0.05）。结论：50~58岁有生育需求中老年男性的精子参数低下,但存在明显的个体差异。Objective： To investigate sperm parameters from semen of men aged 50-58 years who wanted to be father. Methods： Forty-two men aged 50-58 years were enrolled into this study. These men visited the infertility clinic and wanted to be father. Based on their fertility history, 42 men were divided into two groups： group A, 23 cases, 52.9±2.2 （50-58） years, secondary infertility; group B, 19 cases, 52.7±2.7 （50-58） years, primary infertility. According to the WHO manual （2010）, sperm parameters including sperm motility, progressive motility, sperm concentration, sperm abnormal form, teratozoospermia index, and acrosome integrity were determined. Results： Group B had higher sperm abnormal forms than that of group A （P〈0.05）, and the rest sperm parameters were not found significant differences between these two groups （P〉0.05）. According to the WHO reference values, sperm motility and progressive motility in groups A and B did not reach the lower reference limit, and normal morphology in group B did not reach the lower reference limit. In groups A and B, 11 and 5 cases respectively, had normal values on sperm motility, progressive motility, sperm concentration, and sperm normal morphology. Conclusion： Men aged 50-58 years would have poor sperm parameters and obvious individual difference for sperm quality.

关 键 词：精子发生 精子 顶体 衰老 

分 类 号：R698.2[医药卫生—泌尿科学]