扩散加权成像预测和评估鼻窦恶性肿瘤的化疗反应  

Diffusion-weighted imaging in prediction and evaluation of treatment response of malignant sinonasal tumors to chemotherapy

作　　者：陈青华[1] 张冰[2] 赵波[1] 郝晖[1] 吴建兴[1] 佟亚健[1] 冯强强[1] 房居高[3] 陈晓红[3] 张树荣[2] 鲜军舫[1,4] 

机构地区：[1]首都医科大学附属北京同仁医院放射科,北京100730 [2]首都医科大学附属北京同仁医院肿瘤中心,北京100730 [3]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730 [4]鼻病研究北京市重点实验室,北京100730

出　　处：《中国医学影像技术》2014年第7期969-973,共5页Chinese Journal of Medical Imaging Technology

基　　金：北京市优秀人才培养资助D类(2010D003034000033);北京市卫生系统高层次卫生技术人才学科骨干(2011-3-047);北京市自然科学基金(7112030)

摘　　要：目的探讨DWI在预测和评估鼻窦恶性肿瘤化疗反应中的价值。方法对8例鼻窦恶性肿瘤患者化疗前、化疗后第7、21、42天行DWI,分别测量肿瘤最小ADC值(ADCmin)和最大层面ADC值(ADC最大层面),并计算化疗后肿瘤ADC值变化情况。结果与化疗前比较,5例有反应者在化疗后第7、21、42天肿瘤ADC值平均变化率较大,均超过了50%;3例无反应者化疗后第7、21、42天肿瘤ADC值平均变化率较小,无明显升高趋势。结论 ADC值有望能够预测和早期评估鼻窦恶性肿瘤对化疗的反应。Objective To investigate the value of DWI in prediction and evaluation of the response to chemotheraphy in patients with malignant sinonasal tumors. Methods Totally 8 patients with malignant sinonasal tumors underwent DWI before chemotheraphy and 7th, 21st and 42nd days after chemotheraphy. The apparent diffusion coefficient values in the biggest section of the tumor were assessed and the change rate of ADC values after chemotheraphy was calculated. Results Compared to ADC values before chemotheraphy, the change rate of the ADC values increased more than 50% on the 7th, 21st and 42nd days in five patients with treatment response, whereas the change rate did not increase significantly in three patients without treatment response. Conclusion ADC values might be potentially useful for the prediction and evaluation of treatment response to chemotheraphy in patients with malignant sinonasal tumors.

关 键 词：鼻窦 恶性肿瘤 扩散磁共振成像 表观扩散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.62[医药卫生—诊断学]