猕猴桃根多糖脂质体对D-半乳糖胺所致小鼠实验性急性肝损伤的药效作用  

Pharmacodynamics effects of APPS Liposome on acute liver injury induced by D-galactosamine in experimental mice

作　　者：李晓黎[1] 戴文芸[2,3] 石森林[2] 吴瑾瑾[2] 朱雨晴[2] 

机构地区：[1]绍兴市人民医院 [2]浙江中医药大学 [3]杭州市江干区四季青街道社区卫生服务中心

出　　处：《中国临床药理学与治疗学》2014年第6期611-614,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省自然科学基金(Y2101417);浙江省科技计划重点项目(2008C23068)

摘　　要：目的:研究猕猴桃根多糖(APPS)脂质体对D-半乳糖胺所致小鼠急性肝损伤的保护作用。方法:采用D-半乳糖胺所致小鼠急性肝损伤模型,以联苯双酯为对照药,以小鼠血清中ALT、AST等为指标,评价APPS脂质体的抗急性肝损伤作用。结果:APPS脂质体口服液高剂量(200mg/kg)对D-半乳糖胺所致小鼠急性肝损伤药效作用结果显著(P<0.05或P<0.01)。低剂量(50mg/kg)对各肝损伤模型的治疗则无显著性意义(P>0.05)。结论:APPS脂质体口服液对小鼠急性肝损伤有较好的保护作用。AIM： To study the preventive and therapeutic effects of APPS Liposome on mice acute liver injury induced by D-galactosamine. METHODS： D-galactosamine was given to establish the acute liver damaged mouse models. ALT, AST in mice blood were examined as in- dexes to study on the antiacute liver injury effect of APPS Polyphase liposome oral liquid, with bifendate as a control drug. RESULTS ： High dosage of APPS Polyphase liposome （200 mg/ kg） have a significant effect on the acute liverdamaged mice models（P〈0.05 or P〈0.01）, low dosage（50 mg/kg）has no significant effect on the models （P 〉0.05）. CONCLUSION： The results indicated that preventive and therapeutic effects of APPS Polyphase Liposome on mice acute liver injury are significant.

关 键 词：APPS脂质体 D-半乳糖胺所致肝损伤 防治作用 

分 类 号：R965.2[医药卫生—药理学]