炎症牙髓干细胞:起步研究与未来发展  

Inflamed dental pulp stem cells: initial research and future development

作　　者：赵华翔[1] 赵珊梅[2] 辛欣[1] 张博[1] 马宁虎 李沐嘉 张梦琦[1] 李昂[3] 

机构地区：[1]西安交通大学口腔医院,陕西省西安市710004 [2]西安交通大学口腔医院牙周黏膜科,陕西省西安市710004 [3]西安交通大学口腔医院中心实验室,陕西省西安市710004

出　　处：《中国组织工程研究》2014年第23期3756-3761,共6页Chinese Journal of Tissue Engineering Research

基　　金：西安交通大学本科生科研训练与实践创新基金资助(2013289)~~

摘　　要：背景:炎症牙髓干细胞是近年来新发现的一类牙髓干细胞,目前尚无对其研究进展的系统评价。目的:系统评价炎症牙髓干细胞的研究进展。方法:以"(Pulptis OR Inflam*Dental Pulp*OR Human Dental Pulp with Irreversible Pulpitis)AND Stem Cell*/(牙髓炎OR炎症牙髓OR不可逆性牙髓炎)AND干细胞"为检索词检索PubMed、Web of Science、CNKI、WanFang及VIP数据库(时间:建库至2014年2月),同时手检纳入研究的参考文献。对研究结果进行定性分析,进行炎症牙髓干细胞研究进展的全面总结。结果与结论:共纳入11篇文献进行研究,全面阐述炎症牙髓干细胞的研究历史、材料来源、细胞培养、表面标志、扩增能力、多向分化能力、动物模型及临床应用前景的研究进展。炎症牙髓干细胞研究尚处于起步,培养条件和动物模型的建立正处于探究阶段,扩增能力和多向分化能力研究结果尚有争议,而在免疫特性、亚群研究和临床应用方面研究较少。BACKGROUND：Inflamed dental pulp stem cells are a new kind of dental pulp stem cells, and there is no systematic review on the cells by now. OBJECTIVE：To systematical y review the research progress in inflamed dental pulp stem cells. METHODS：A computer-based online search in PubMed, Web of Science, CNKI, WanFang and VIP databases was performed for related articles published from the establishment of the databases to February 2014. The keywords were“（pulptis or inflam＊dental pulp＊or human dental pulp with irreversible pulpitis） and stem cel＊”in English and Chinese, respectively. Hand searching was also done to obtain further information or papers about the studies. The results were qualitatively analyzed to comprehensively summarize the progress in the research of inflamed dental pulp stem cells. RESULTS AND CONCLUSION：Total y 11 papers were involved in result analysis that comprehensively review the research progress in inflamed dental pulp stem cells at the fol owing aspects：the research of history, material origin, cellculture, cel-surface markers, proliferation ability, multi-directional differentiation potential, animal models and clinical use. Researches of inflamed dental pulp stem cells are stil in the initial stage, and cultivating conditions and the establishment of animal models are stil in the exploratory phase. Controversies stil exist in the capacity of proliferation and multi-directional differentiation of the inflamed dental pulp stem cells. And fewer studies have been done in the characteristics of immunity, subpopulation and clinical use of the inflamed dental pulp stem cells.

关 键 词：干细胞 培养 炎症牙髓干细胞 表面标志 多向分化能力 扩增能力 研究进展 

分 类 号：R318[医药卫生—生物医学工程]