甲状腺肿瘤干细胞与甲状腺肿瘤治疗:理论与应用  

Thyroid cancer stem cells and thyroid cancer treatment: theory and applications

作　　者：赛恒 毕力夫[1] 吴岩[2] 

机构地区：[1]内蒙古医科大学,内蒙古自治区呼和浩特市010110 [2]内蒙古医科大学组胚教研室,内蒙古自治区呼和浩特市010110

出　　处：《中国组织工程研究》2014年第23期3762-3767,共6页Chinese Journal of Tissue Engineering Research

基　　金：内蒙古自治区自然科学基金(5012012-00N0-N00041CZT)~~

摘　　要：背景:研究发现甲状腺肿瘤干细胞促进肿瘤的发生发展,是肿瘤耐药的原因之一。对甲状腺肿瘤干细胞的认识与研究,可以为甲状腺肿瘤的诊断与治疗提供一些新的思路。目的:对甲状腺肿瘤干细胞的发现、鉴定识别、与肿瘤的关系及其临床应用进行综述。方法:由作者应用计算机检索PubMed、万方数据库中1995年1月至2014年1月相关文献。在标题、摘要、关键词中以"thyroid cancer,cancer stem cell,stem cell,cancer suppressor gene"或"甲状腺肿瘤、肿瘤干细胞、干细胞,肿瘤抑癌基因"为检索词进行检索。选择文章内容与甲状腺肿瘤干细胞有关者,同一领域则选择近期发表在权威杂志上的文章。结果与结论:初检得到文献561篇,根据标准纳入57篇文献进行综述。肿瘤干细胞目前已成为肿瘤病因研究的热点。甲状腺及其肿瘤中也存在干细胞,目前可以通过一定的方法鉴别并分离甲状腺肿瘤干细胞。甲状腺肿瘤干细胞与肿瘤的发生、转移以及肿瘤的治疗息息相关,但是否可以通过抑制或根除肿瘤干细胞来治疗甲状腺肿瘤需要深入研究。BACKGROUND：Thyroid cancer stem cells are one of the reasons for tumor resistance that promotes tumor development. The research of thyroid cancer stem cells has provides a new clinic means for the diagnosis and treatment of thyroid cancer. OBJECTIVE：To overview the discovery, identification, and correlation of thyroid cancer stem cells with thyroid cancer. METHODS：A computer-based online search of PubMed database and Wan Fang database between 1995-01/2014-01 was performed to search related articles with the key words of“thyroid cancer, cancer stem cell, stem cell, cancer suppressor gene”in English and Chinese, respectively. Literatures related to thyroid cancer stem cells were selected;in the same field, the articles published lately in authoritative journals were preferred. RESULTS AND CONCLUSION：A total of 561 literatures were primarily selected, and 57 documents were involved for result analysis according to inclusion criteria. Cancer stem cells have become a focus in the study of carcinogenesis. Stem cells also exist in the thyroid gland and its tumor. At present, there are several ways to isolate and identify thyroid cancer stem cells. The tumor thyroid stem cells are closely related to the occurrence, transfer and treatment of tumors. But whether we can cure thyroid cancer through restraining or eliminating thyroid cancer stem cells is stil unknown that needs further studies.

关 键 词：干细胞 肿瘤干细胞 甲状腺肿瘤 肿瘤抑癌基因 内蒙古自治区自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]