壳聚糖膜在治疗宫颈疾病中的降解时间与影响因素的研究  

Study on Degradation Time and Influencing Factors of Chitosan Membrane in the Treatment of Cervical Diseases

作　　者：刘真淋 付正英[2] 安艳辰 程红梅[1] 

机构地区：[1]天津中医药大学,天津300073 [2]武警后勤学院附属医院,天津300162

出　　处：《现代生物医学进展》2014年第25期4816-4818,共3页Progress in Modern Biomedicine

摘　　要：目的:研究不同壳聚糖膜在体外及体内的生物降解时间。方法:用不同分子量壳聚糖为制膜材料,将4组不同组成成分的壳聚糖溶于1.5%乙酸中,配成1%溶液,加入辅料烘干成膜称其重量,剪成大小相等的小块,精称后放置于弱酸介质和雌鼠阴道中。定时取样,水洗,烘干后称重,按W-W'W×100%算得降解百分率。结果:1号较2号降解时间快,而加入PVA的3号与4号又较1号与2号更快。结论:壳聚糖是一种生物可降解材料,壳聚糖膜的降解时间与其分子量、PVA比例、介质酸性强度等因素相关。Objective： To explore the vitro and vivo degradation time of chitosan films. Methods： Using chitosan with different molecular weight as the membrane material, four groups of different compositions of chitosan dissolved in 1.5% acetic acid, Formulated as a 1% solution, after drying and weighing adding accessories, Cut into pieces of equal size, weighed and placed in a weak acid medium and Female rats vagina. Regular sampling, washed, dried and weighed. Calculated the percentage degradation by W-W＇/W× 100 % W Results： No.1 is faster than No.2, PVA added in the No.3 and No.4 is faster than No.1 and No.2. Conclusion： chitosan is a kind of biodegradable material, the degradation of chitosan membrane is related to its molecular weight, PVA ratio and the acidic strength of the medium etc.

关 键 词：壳聚糖 膜 降解 宫颈疾病 

分 类 号：R711.32[医药卫生—妇产科学] R318.08[医药卫生—临床医学]