IGF-Ⅱ、IGF-lR、IGFBP-3在结直肠癌中的表达及诊断价值研究  

Expression and Diagnostic Value of IGF- Ⅱ, IGF-l R, IGFBP-3 in Colorectal Cancer

作　　者：王全晖[1] 郭树军[1] 张春旭[1] 张元浩[1] 郭宁辉[1] 

机构地区：[1]解放军第153中心医院普通外科,河南郑州450042

出　　处：《现代生物医学进展》2014年第24期4698-4700,4685,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨结直肠癌中IGF-Ⅱ、IGF-l R以及IGFBP-3等的阳性表达及诊断价值。方法:收集我院45例结直肠癌、33例炎性息肉、40例腺瘤以及35例正常肠粘膜组织予以免疫组织化学SP法进行IGF-Ⅱ、IGF-l R以及IGFBP-3检测,并统计结直肠腺瘤不同组织类型和结直肠癌不同Dukes分期的阳性表达差异。结果:结直肠癌组织中IGF-Ⅱ、IGF-l R以及IGFBP-3表达均呈高阳性率,并且显著高于其他3组(P<0.05)。结直肠腺瘤管状、混合型、绒毛状等不同组织类型IGF-Ⅱ、IGF-l R以及IGFBP-3表达阳性率呈逐渐增高趋势,绒毛状腺瘤显著高于其他两型(P<0.05)。45例结直肠癌中,Dukes分期A、B两期显著低于C期和D期,比较差异具有显著性(P<0.05)。结论:IGF-Ⅱ、IGF-l R以及IGFBP-3可能在结直肠腺瘤发生、发展及进展为结直肠癌的过程中起一定作用,对结直肠癌早期诊断具有一定价值。Objective： To investigate the value of positive expression and diagnosis of colorectal cancer IGF- Ⅱ, IGF-1 R and IGFBP-3 etc. Method： 45 cases of colorectal cancer, 33 cases of inflammatory polyp, 40 cases of adenoma, 35 cases of normal intestinal mucosa in our hospital were selected, immunohistochemical SP method was used to detect IGF- Ⅱ, IGF-1 R and IGFBP-3, the positive expression of different tissues of colorectal adenoma and different type Dukes colorectal cancer staging were compered. Results： The colorectal cancer tissue showed a high positive rote oflGF- Ⅱ, IGF-I R and IGFBP-3 expression, and were significantly higher than the other 3 groups （P〈0.05）. Colorectal adenoma tubular, mixed type, villous, different tissue types of IGF- Ⅱ, IGF-1 R, the positive rate of IGFBP-3 expression was gradually increased, villous adenoma was significantly higher than that of other two types （P〈0.05）. In 45 cases of colorectal carcinoma, Dukes stage A, B period was significantly lower than that of C phase and D phase, and the difference was significant （P〈0.05）. Conclusion： IGF- Ⅱ, IGF-I R, and IGFBP-3 may play a role in the process of colorectal adenoma occurrence and progression to colorectal cancer, and have a certain clinical value in early diagnosis ofcolorectal cancer.

关 键 词：阳性率 结直肠癌 诊断 表达 

分 类 号：R722[医药卫生—儿科]