右美托咪定对子宫肌瘤切除术患者全麻苏醒期应激反应的影响  

Effects of Dexmedetomidine on the Stress Reactions of Intravenous Anesthesia for Patients with Hysteromyomectomy

作　　者：许喆[1] 杨洋 刘霞[3] 满元元[1] 郭晓东[3] 

机构地区：[1]解放军总医院麻醉手术中心,北京100853 [2]河南省南阳市骨科医院麻醉科,河南南阳473054 [3]解放军第302医院,北京100039

出　　处：《现代生物医学进展》2014年第24期4757-4759,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨盐酸右美托咪定用于全凭静脉麻醉对子宫肌瘤切除术患者应激反应的影响。方法:选择我院收治的择期行子宫肌瘤切除术患者60例,随机分为观察组和对照组,每组30例。两组患者均采用全麻,其中观察组患者在麻醉诱导15 min内静脉输注1 ug/kg盐酸右美托咪定注射液,术中0.3-0.6 ug/(kg×h)维持;而对照组患者采用静脉输注0.9%的Nacl溶液。分别于麻醉前、麻醉后及苏醒期测定并观察两组患者外周静脉血中TNF-α,IL-2和IL-6的浓度变化情况。结果:两组患者麻醉前TNF-α,IL-2和IL-6的浓度无显著性差异(P>0.05)。两组患者麻醉后及苏醒期TNF-α,IL-2及IL-6浓度均显著高于麻醉前,差异具有统计学意义(P<0.05)。观察组患者麻醉后及苏醒期TNF-α,IL-2及IL-6浓度均显著低于对照组,差异具有统计学意义(P<0.05)。结论:右美托咪定用于全凭静脉麻醉对子宫肌瘤切除术患者血清TNF-α、IL-2和IL-6浓度具有调节作用,可缓解或降低手术引起的应激反应。Objective： To discuss the effects of dexmedetomidine on the stress reactions of intravenous anesthesia for patients with the hysteromyomectomy. Methods： 60 patients who were undergoing the hysteromyomectomy in our hospital were selected and randomly divided into the observation group and the control group with 30 cases in each one. All the patients were taken the intravenous anesthesia. The patients in the observation group were induced by the dexmedetomidine hydrochloride injection with 1 ug/kg in 15 min, and kept in the operation with 0.3-0.6 ug/kg （h）. While the patients in the control group were treated by the intravenous infusion with 0.9% Nacl. Then the concentrations ofTNF-α, IL-2 and IL-6 in the serum of patients before the anesthesia, after the anesthesia and the recovery were detected and compared. Results： There was no statistically significant difference about the concentrations of TNF-α, IL-2 and IL-6 of patients in the two groups before the anesthesia（P〉0.05）. The concentrations of TNF-α, IL-2 and IL-6 of patients after the anesthesia and in the recovery were higher than before with statistically significant differences（P〈0.05）. The concentrations of TNF-α, IL-2 and IL-6 of patients in the observation group were lower than those of the patients in the control group with statistically significant differences（P〈0.05）. Conclusion： It is indicated that the dexmedetomidine could alleviate or reduce the anesthetic stress reactions of patients with hysteromyomectomy by means ofregnlating the concentrations of TNF-α, 1L-2 and IL-6 in serum.

关 键 词：盐酸右美托咪定 子宫肌瘤切除术 应激反应 全凭静脉麻醉 

分 类 号：R614[医药卫生—麻醉学]