1型糖尿病患者骨密度的变化及相关因素分析(英文)  

A Study of Bone Mineral Density and its Determinants in Type 1 Diabetes Mellitus

作　　者：孙明霞[1] 贾兆通[1] 李长贵[1] 田凯华[1] 魏梅[1] 刘明娣[1] 

机构地区：[1]青岛大学医学院附属医院,山东青岛266003

出　　处：《现代生物医学进展》2014年第26期5092-5095,共4页Progress in Modern Biomedicine

基　　金：National Natural Science Foundation of China(90202016)~~

摘　　要：目的:观察1型糖尿病患者骨密度(bone mineral density,BMD)的变化及其影响因素。方法:采用双能X线骨密度仪测定108例1型糖尿病患者及106例非糖尿病人群腰椎1至4(L1、L2、L3、L4、、L1-4总体)及左侧髋部(股骨颈、大转子、ward's三角、股骨干及左髋总体)骨密度,同时测定受试者年龄、身高、体重、腰围、臀围,1型糖尿病患者病程、糖化血红蛋白(HbA1c)等指标,利用多元回归分析1型糖尿病患者骨密度的相关因素。结果:L1-4总体BMD和左髋总体BMD与年龄、HbA1c呈负相关,与BMI呈正相关(P<0.05);左髋总体BMD与性别有关(P<0.05)。结论:1型糖尿病患者BMD低于对照人群,1型糖尿病患者的性别、年龄、BMI、HbA1c水平与BMD关系密切。Objective： To explore the changes of the bone mineral density （BMD） and the relationship between BMD and clinical related factors in type 1 diabetic patients. Methods： BMD in lumbar spine and hip in 108 type 1 diabetic patients and 106 control subjects were measured by using Dual-energy X-ray Absorptiometry （DXA）. In all subjects, age, height, body weight, waistline, hips were measured, in type 1 diabetic patients, Diabetes duration and HbAlc were assessed. Results： BMDs of lumbar 1 （L1）, lumbar 2 （L2）, lumbar 3（L3）, lumbar 4 （IA）, lumbar 1-4 （L1-4） total, Neck, Troeh, ward＇s, Trunk and hip total were significantly lower in type 1 diabetic patients than control subjects. In type 1 diabetic patients, there were significant positive correlation between body mass index （BMI） and BMDs of L1, L2, L1-4 total, Neck, Troch, Tnmk and hip total. In type-1 diabetic patients, HbAlc level and age was negatively correlated and BMI was positively correlated with L1-4 total BMD and left hip total BMD （P〈0.05）. Gender was correlated with left hip total BMD （P〈0.05）. Conclusions： BMD of type 1 diabetic patients were significantly lower than that of control subjects. Gender, age, BMI and HbAlc were related to the BMD in type 1 diabetic patients.

关 键 词：1型糖尿病 骨密度 影响因素 

分 类 号：R587.1[医药卫生—内分泌]