早期离断及外用中药疗法对糖尿病足坏疽创面残端局部组织细胞因子VEGF、3-NT的影响  

Effects of Early-amputation Combined with External Therapy with Herbal Medicine on VEGF and 3-NT in Local Tissue of Wound Surface

作　　者：王宽宇[1] 陈静[1] 赵可君[1] 吴明远 李承[1] 赵振宇[1] 姜桂云[1] 王旭[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,哈尔滨150040 [2]美国俄克拉哈马大学健康科学中心糖尿病研究中心

出　　处：《中国中医药科技》2014年第4期358-359,390,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：教育部"春晖计划"合作科研项目No.Z2009-1-15034

摘　　要：目的:探讨早期离断及外用中药疗法对创面局部组织细胞因子VEGF、3-NT的作用。方法:选取45例糖尿病足患者,随机分成观察组、对照1组和对照2组,每组15例。观察组采用早期离断术后外用中药治疗,对照1组采用早期离断普通外科换药,对照2组采用高位截肢普通外科换药。分别于不同时段采用ELISA法检测残端创面局部组织VEGF、3-NT含量。结果:术后用药两周,观察组创面局部组织VEGF含量变化较两对照组明显升高(P<0.01),3-NT含量变化较两对照组明显降低(P<0.01)。结论:早期离断外用中药有效治疗糖尿病足坏疽的作用机制之一为增加创面局部组织中的VEGF含量,降低3-NT含量。Objective：To explore the effects of early-amputation combined with external therapy with herbal medicine on VEGF,3-NT in local tissue of the wound surface.Methods：45 cases of diabetic foot patients were divided into three groups（observation group,control group 1 and control group 2） randomly with each group accommodating 15 cases.Observation group cured with early-amputation combined external therapy with herbal medicine.Control group 1 cured by early-amputation with routine surgical dressing.Control group 2 treated with high amputation and routine surgical dressing.ELISA method was applied to detect the contents of VEGF and 3-NT in the local tissue of the stump.Results：Medicating in postoperative two weeks,the content of VEGF in observation group was increased obviously to compare with the two control groups（P 〈0.01）,the content of 3-NT was decreased obviously to compare with the two control groups （P 〈0.01）.Conclusion：To improve the level of VEGF and reduce the level of 3-NT in local tissue is one of the principles in the treatment by early-amputation combined external therapy with herbal medicine.

关 键 词：早期离断 糖尿病足坏疽 血管内皮生长因子(VEGF) 3-硝基酪氨酸(3-NT) 

分 类 号：R587.2[医药卫生—内分泌]