益智茎叶中黄酮类化学成分研究  

Chemical Constituents of Flavones Part from the Stems and Leaves of Alpinia oxyphylla Miq.

作　　者：李洪福[1,2] 谭银丰[1,2] 王勇[1,2] 魏娜[1] 李永辉[1,2] 张俊清[1,2] 

机构地区：[1]海南医学院药学院 [2]海南医学院海南省热带药用植物研究与开发重点实验室,海口571101

出　　处：《天然产物研究与开发》2014年第7期1038-1042,共5页Natural Product Research and Development

基　　金：海南医学院科研培育基金项目(HY2012-018);国家"十二五"区域基地项目(SQ2010BAJY1411-07-02);海口市重点科技计划项目(ZDXM20110037)

摘　　要：对益智茎叶中黄酮类化学成分进行研究,采用多种色谱方法进行分离纯化,运用多种谱学方法并结合理化性质对分离得到的化合物进行结构鉴定。结果从益智茎叶95%乙醇提取物中共分离得到11个黄酮类化合物,其中包括8个黄酮类化合物,分别鉴定为:良姜素(izalpinin)(1)、杨芽黄素(tectochrysin)(2)、白杨素(chrysin)(3)、芹菜素(apigenin)(4)、刺槐素(acacetin)(5)、5-羟基-4',7-二甲氧黄酮(5-hydroxy-4',7-dimethoxyflavone)(6)、山奈酚-4'-O-甲醚(kaempferol-4'-O-methylether)(7)、5,7,4'-三甲氧基黄酮(5,7,4'-trimethoxyflavone)(8)和3个二氢黄酮类化合物,分别鉴定为:乔松素(pinocembrin)(9)、球松素(pinostrobin)(10)和二氢山萘酚(dihydrokaempferol)(11)。所有化合物均为首次从该植物茎叶中分离得到,其中化合物6、8和10为首次从该属植物中分离得到。To study the chemical constituents of flavones from the stems and leaves ofAlpinia oxyphyUa Miq.. The chem- ical constituents were isolated by using various column chromatographies and their structures were dueidated on basis of physicochemical constants and spectral data analysis. Consequently,eight flavones and three flavanones were obtained from the 95% ethanol extracts of the stems and the leaves ofAlpinia oxyphylla Miq.. Their structures were determined to be izalpinin （ 1 ）, tectochrysin （ 2 ）, chrysin （ 3 ）, apigenin （ 4 ）, aeacetin （ 5 ）, 5-hydroxy-4＇, 7-dimethoxyflavone （ 6 ）, kaempferol-4＇-O-methylether （ 7 ）, 5,7,4＇-trimethoxyflavone （ 8 ）, pinocembrin （ 9 ）, pinostrobin （ 10 ）, and dihydro- kaempferel（ 11 ）. All those compounds were obtained from the parts of stems and leaves of A. oxyphylla Miq. for the first time, and compounds 6,8, and 10 were obtained from this genus for the first time.

关 键 词：益智 黄酮 化学成分 

分 类 号：R284.2[医药卫生—中药学]