玉郎伞提取物对支气管平滑肌舒张作用的研究  

Relaxation Effect of Different Extracts of Yulangsan on Tracheal Smooth Muscle

作　　者：曾嵘[1,2] 黄建春[1] 陈春霞[1] 付书婕[1] 黄仁彬[1] 

机构地区：[1]广西医科大学药学院 [2]广西区江滨医院,广西南宁530021

出　　处：《天然产物研究与开发》2014年第7期1077-1080,共4页Natural Product Research and Development

基　　金：广西科学研究与技术开发计划项目(0630002-2A)

摘　　要：研究玉郎伞水提物及从玉郎伞中提取纯化的三种活性成份—黄酮、皂苷、多糖对豚鼠离体气管条的舒张作用。实验制备新鲜豚鼠离体气管条,在克氏缓冲液中分别加入组胺或乙酰胆碱,使豚鼠气管螺旋条收缩达高峰后观察不同剂量的玉郎伞水提物及三种活性成份对乙酰胆碱或组胺致气管条收缩的影响。结果表明,玉郎伞水提物及皂苷、多糖能对抗乙酰胆碱或组胺对豚鼠离体气管条的收缩作用,使组胺及乙酰胆碱量效曲线右移。因此,玉郎伞水提物及皂苷、多糖有较强的支气管舒张作用。In order to observe the relaxation effects of total Yulangsan water extract （TYLS） ,and three purified compo- nents of Yulangsan, namely flavonoid, saponin and polysaccharide on guinea pig tracheal smooth muscle, the fresh piece of guinea pig trachea was prepared. The contraction model of the isolated guinea pig trachea was induced by histamine （ His ） or acetylcholinc （ACh） in the Krebs＇ buffer solution. Different concentrations of TYLS and three components were then applied on the contractive tracheal model. The results showed that TYLS, saponin and polysaccharide markedly relieved the contraction of isolated tracheal smooth muscle of guinea pig induced by His or Ach and the concentration-response curves of His and ACh were shifted rightward. The presented data suggested that TYLS, saponin and polysaecharide can significantly relax the tracheal smooth muscle.

关 键 词：玉郎伞水提物 黄酮 皂苷 多糖 离体气管条 

分 类 号：R965.2[医药卫生—药理学]