龙葵生物碱自微乳化制剂配方研究  

Study on Self-microemulsifying Drug Delivery System Formulation for Solanum nigrum Alkaloids

作　　者：张威[1] 贾晓斌[2] 刘美辉[1] 朱劲华[1] 

机构地区：[1]江苏建康职业学院,南京210029 [2]江苏省中医药研究院,南京210028

出　　处：《天然产物研究与开发》2014年第7期1112-1116,共5页Natural Product Research and Development

摘　　要：通过考查自微乳化给药系统(SMEDDS)配方中吐温-20、OP乳化剂、油酸、1,2-二丙醇、龙葵生物总碱提取物等各组分对其粒径和透光率的影响,最终找出龙葵生物碱自微乳化制剂最优的配方,为今后通过正交试验、星点设计等方式进一步探索龙葵生物碱自微乳化制剂最佳配方和研究龙葵生物碱自微乳化制剂的药效研究提供参考。The aim of this study was to find the optimal self-microemulsifying drug delivery system （SMEDDS） formulation for Solanum nigrum alkaloids. The effects of the contents of Tween-20, polyoxyethylane octyl phenyl ether, oleie acid, 1,2-pmpanediol and S. nigrum alkaloids on the particle diameter and light transmittance of SMEDDS for S. nigrum alkaloids were investigated. The optimized ingredients for preparing SMEDDS for S. nigrum alkaloids provided reference for further studies on its pharmaeodynamics.

关 键 词：龙葵 生物碱 自微乳给药系统 粒径 

分 类 号：Q94[生物学—植物学] R28[医药卫生—中药学]