小剂量艾司洛尔对丙泊酚注射痛的缓解作用  

Clinical observation of whether pretreatment with a low dose of esmolol can reduce propofol injection pain

作　　者：姜慧芳[1] 方军[1] 连燕虹[1] 

机构地区：[1]浙江省肿瘤医院麻醉科,杭州市310022

出　　处：《临床麻醉学杂志》2014年第7期676-678,共3页Journal of Clinical Anesthesiology

摘　　要：目的观察预注小剂量艾司洛尔对丙泊酚注射痛的缓解作用。方法 90例在全麻下行乳腺癌根治术患者,随机均分为三组:艾司洛尔组(E组)、利多卡因组(L组)和生理盐水组(N组)。E组静注艾司洛尔5mg/ml,2ml;L组静注利多卡因20mg/ml,2ml;N组静注2ml生理盐水。1min后,按照丙泊酚诱导剂量1mg/kg,先给予1/3剂量,观察三组注射丙泊酚时的疼痛情况,并记录插管前(T1)、插管后即刻(T2)、插管后5min(T3)BP、HR、SpO2的变化。结果与N组比较,E组和L组丙泊酚注射疼痛程度明显下降(P<0.05)。N组丙泊酚注射痛发生率为25例(83.3%),明显高于E组的12例(40.0%)和L组的14例(46.7%)(P<0.05),E组和L组丙泊酚注射痛发生率差异无统计学意义。与T1时比较,T2时E组和L组SBP、DBP和T2时N组SBP明显降低(P<0.05),与T2时比较,T3时E组DBP明显升高(P<0.05)。结论预注小剂量艾司洛尔可缓解丙泊酚注射痛。Objective To investigate the effect of esmolol pretreatment on propofol injection pain..Methods Ninety patients undergoing breast cancer surgery under general anesthesia were ran-domly assigned into three groups （n=30 each）.Group E were pretreated with 5 mg/ml（total 2 ml）es-molol group L with 20 mg/ml （total 2 ml）lidocaine and group N with 2 ml normal saline.After one minute,each group was administrated propofol intravenouly.The pain and hemodynamic data were re-corded.Results Compared with group N,propofol injection pain degree decreased obviously in groups E and L （P 〈0.05）.propofol injection pain occurred in 25 （83.3%）in group N,was signifi-cantly higher than that of 12 （40.0%）in group E and 14 （46.7%）in group L （P 〈0.05）,propofol injection pain had no significant difference between groups E and L.Compared with T1 ,SBP,DBP decreased in groups E and L at T2 ,SBP decreased in group N at T2 significantly （P 〈0.05）.Com-pared with T2 ,DBP was significantly higher at T3 in group E （P 〈0.05）.Conclusion Pretreatment with low dose esmolol was effective in attenuating pain during propofol injection.

关 键 词：艾司洛尔 丙泊酚 注射痛 

分 类 号：R614[医药卫生—麻醉学]