α1肾上腺素能受体阻滞剂萘哌地尔在慢性非细菌性前列腺炎治疗的临床分析  

The Clinical Analysis of α1 Adrenergic Receptor Blockers Naftopidil in Chronic Non Bacterial Prostatitis Treatment

作　　者：杨海帆[1] 

机构地区：[1]泸州医学院附属医院泌尿外科,四川泸州646000

出　　处：《航空航天医学杂志》2014年第7期906-907,共2页Journal of Aerospace medicine

摘　　要：目的研究α1肾上腺素能受体阻滞剂萘哌地尔在NBP(慢性非细菌性前列腺炎)的临床治疗上是否安全有效。方法采取多中心、开放的临床研究方法,选取110例NBP患者并对其治疗四个星期。治疗所获得的各项指标均按照EPS(美国国立卫生院前列腺液)WBC计数及最大尿流量、NIH-CPSI(慢性前列腺炎症状评分)作为参考指标,对该药物的安全性以及有效性进行测评。结果在四周的治疗之后,110例患者中有109例可进行评价。全组患者治疗前后的生活质量评分平均降低4.1分,症状评分平均降低了7.9分,NIH-CPSI总评分平均降低了12.0分。治疗前后的MFR分别为(19.24-4.8)、(22.74-4.9)mL/s。EPS中治疗前及治疗后的WBC计数分别为(15.24-15.1)、(9.54-12.0)个/HP。若评价标准为病人的症状改善情况,则17例患者治疗无效约占总体的15.6%,56例患者治疗有效约占总体51.4%,33例患者治疗显效约占总体30.3%,3例患者治愈约占总体的2.7%。治疗的总有效率为84.4%。在治疗过程中有2两例患者出现食欲不振,4例患者出现轻度头晕的症状,总体不良事件发生率为3.81%。结论可见萘哌地尔在临床治疗慢性非细菌性前列腺炎上有效、安全。Objective The alpha 1 adrenergic receptor blockers naphthalene in er in NBP（ chronic abacterial prostatitis） on the clinical treatment of whether is safe and effective. Methods Take the multi-center clinical research methods,open,select 110 patients with NBP and its therapy for four weeks. All the indexes obtained by the treatment according to the EPS（ the us national institutes of health prostate fluid） the WBC count and maximum urinary flow rate,the NIH-CPSI（ scores） of chronic prostatic inflammation as a reference index,safety and efficacy of the drug evaluation. Results In four weeks after the treatment of 110 cases of patients with 109 cases can be evaluated. The quality of life score in all patients before and after treatment by an average of 4. 1 points,symptom scores by an average of 7. 9points,the NIH-CPSI total score by an average of 12. 0 points. Before and after treatment of MFR,respectively（ 19. 24-4. 8）,（ 22. 74-4. 9） mL /s. EPS before and after treatment in the WBC count,respectively（ 15. 24-15. 1）,（ 9. 54-12. 0） /HP. If the evaluation standard for the patient＇s symptoms improved situation,17 patients treatment is invalid accounts for about 15. 6% of the total,56 patients with effective treatment accounted for about 51. 4% overall,33 cases patients accounts for about 30. 3% overall were markedly improved,3 cases of patients cured accounted for about 2. 7%of the total. Treatment the total effective rate was 84. 4%. 2 two patients appeared in the process of treatment of anorexia,4 cases of patients with a mild symptoms of dizziness,the overall incidence of adverse event. Conclusions Naphthalene in visible,in clinical treatment of chronic nonbacterial prostatitis,effective and safe.

关 键 词：α1肾上腺素能受体阻滞剂萘哌地尔 慢性非细菌性前列腺炎 临床分析 

分 类 号：R697[医药卫生—泌尿科学]