114例注射用赖氨匹林不良反应分析  

Adverse drug reactions induced by aspirin-DL-lysine for injection in 114 patients

作　　者：崔向丽[1] 王颖[1] 刘丽宏[1] 邱爽[1] 王华光[1] 张征[1] 赵志霞[1] 

机构地区：[1]首都医科大学附属北京朝阳医院药事部,北京100020

出　　处：《中国新药杂志》2014年第14期1717-1720,共4页Chinese Journal of New Drugs

摘　　要：目的:收集北京地区医疗机构近6年注射用赖氨匹林不良反应报告,对其临床特征和相关因素进行深入分析,为规避临床用药风险提供参考。方法:对114例注射用赖氨匹林的不良反应发生特点、规律和预后进行归纳、分析。结果:赖氨匹林引起的不良反应有46.5%由于合并用药引起,主要是合并抗感染药物静脉滴注,40.4%是否合并用药不详,仅有13.2%是单独用药引起。不良反应58.8%是皮肤过敏反应,其他包括胃肠反应、肝肾功能损害等。经过对症处理,基本都好转。结论:赖氨匹林单独肌注或静脉使用的安全性高,与其他药物混合输注不良反应发生率高,应引起医务人员高度重视,12岁以下儿童慎用赖氨匹林,3岁以下禁用。Objective：To analyze clinical features and related factors of adverse drug reactions（ADR） induced by aspirin-DL-lysine for injection reported by hospitals in Beijing district in the past six years,so as to prefer a reference for avoiding the risk of clinical drug use.Methods：A total of 114 patients with ADR induced by aspirin-DL-lysine were collected and retrospectively analyzed.The characteristics,patterns and prognosis of ADR were summarized and analyzed.Results：In the ADR,46.5% were caused by combination use with other drugs,and most of the combined drugs were antibiotics.In 40.4% patients,whether ADR was caused by combination with other drugs was unknown.Only 13.2% of the ADR were induced by aspirin-DL-lysine alone.Most of the ADR（58.8%） were skin allergic reactions,other reactions included gastrointestinal reactions,liver and kidney impairment,etc.After symptomatic treatment,the ADR recovered.Conclusion：Intramuscular injection or intravenous use of aspirin-DL-lysine alone is safe.ADR could be induced in a high incidence by infusions mixed with other drugs;thus these false uses should be avoided.In children younger than 12 years old aspirin-DL-lysine should be used with caution,and in children less than 3 years old it should be prohibited.

关 键 词：赖氨匹林 不良反应 过敏反应 联合使用 

分 类 号：R971.1[医药卫生—药品]