三七总皂苷对大鼠扭体模型的镇痛作用  

Analgesic effect of panax notoginseng saponins on rat writhing models

作　　者：杨帆[1] 刘红[1] 万炜[1] 

机构地区：[1]南华大学人体解剖学教研室,湖南衡阳421001

出　　处：《中医临床研究》2014年第9期70-71,共2页Clinical Journal Of Chinese Medicine

摘　　要：目的:观测三七总皂苷对大鼠扭体模型的镇痛作用。方法:24只SD大鼠随机分为生理盐水对照组(n=12)、三七总皂苷组(n=12),各组大鼠腹腔给药,12h一次,给药7天。于第8天给药后30min腹腔注射乙酸建立扭体模型,观测给药后15min扭体反应次数。结果:三七总皂苷具有较强的镇痛作用,三七总皂苷组大鼠扭体反应次数明显少于生理盐水对照组(P<0.01)。结论:三七总皂苷对乙酸所致大鼠扭体模型有一定的镇痛作用。Objective：To observe the analgesic effect of panax notoginseng saponins on rat writhing models.Methods：24 SD rats were randomly divided into a saline control group （n=12） and a panax notoginseng saponins group（n=12）.The rats were taken intraperitoneal administration,12 hours once for 7 days.After the administration 30 minutes in the 8th day,rats were taken acetic acid intraperitoneal administration. The frequency of body torsion reaction after administration was observed.Results：Panax notoginseng saponins has remarkable analgesic effects and the frequency of panax notoginseng saponins group is much less than that of saline control group（ P〈0.01）.Conclusion：Panax notoginseng saponins has analgesic effect on rat writhing models by acetic acid.

关 键 词：三七总皂苷 扭体模型 镇痛 

分 类 号：R285.5[医药卫生—中药学]