疏血通注射液治疗高脂血症性重症急性胰腺炎临床分析  

Clinical analysis of Shuxuetong injection in treatment of acute severe hyperlipidemic pancreatitis

作　　者：张振波[1] 丁国娟[1] 任疆[1] 赵瑞芳[2] 范福玲[3] 

机构地区：[1]浙江省绍兴市人民医院(浙江大学绍兴医院)急诊科,312000 [2]浙江省绍兴市人民医院(浙江大学绍兴医院)心内科,312000 [3]漯河医学高等专科学校第三附属医院急诊科,河南省漯河市462002

出　　处：《中华全科医学》2014年第10期1556-1558,共3页Chinese Journal of General Practice

摘　　要：目的探讨疏血通注射液治疗高脂血症性重症急性胰腺炎(HLSAP)的效果。方法将102例HLSAP患者分成2组。对照组常规治疗,观察组加用疏血通注射液,比较治疗前后血清TG、血和尿淀粉酶(AMS)、C反应蛋白(CRP)、前白蛋白、TNF-α、SIRS、APACHEⅡ、Ranson评分。观察血液流变学指标的变化和并发症。结果观察组治疗后TG、血液流变学各指标、CRP、TNF-α、SIRS评分、APACHEⅡ评分、Ranson评分较治疗前明显下降(P<0.05或P<0.01),前白蛋白明显上升(P<0.01)。对照组治疗后TG、全血黏度高/低切变率、血细胞比容、CRP、TNF-α、SIRS评分、APACHEⅡ评分较治疗前明显下降(P<0.05),前白蛋白明显上升(P<0.05)。2组血、尿AMS较治疗前变化不明显(P>0.05)。观察组TG、血浆比黏度、纤维蛋白原、血小板聚集率、红细胞沉降率、CRP、TNF-α、前白蛋白、(SIRS、APACHEⅡ、Ranson)评分较对照组变化明显(P<0.05),呼吸衰竭、肾衰竭、胸腹腔积液发生率明显低于对照组(P<0.05)。结论疏血通注射液能降低TG水平,改善微循环障碍,维持促抗炎细胞因子平衡,改善预后。Objective To investigate the clinical effect of Shuxuetong injection in the treatment of acute severe hyperlipidemic pancreatitis. Methods A total of 102 cases of acute severe hyperlipidemic pancreatitis were divided into two groups. The control group was given the conventional therapy,while the observation group was added Shuxuetong injection based on the conventional treatment. The levels of serum TG,amylase（ AMS） in the blood and urine,C reactive protein（CRP） and TNF-α,and SIRS score,APACHEⅡ score and Ranson score were recordeded and compared before and after the treatment. The blood rheology index and the incidence of complications were also observed. Results In the observation group,the levels of TG,CRP and TNF-α,the index of hemorheology,SIRS score,APACHEⅡ score and Ranson score were decreased after treatment（P〈0. 05 or P〈0. 01）,but the level of prealbumin increased significantly（P〈0. 01）. In the control group,the levels of TG,CRP and TNF-α,whole blood viscosity（ WBV） at high /low shear rate,hematocrit,SIRS score and APACHEⅡ score decreased after the treatment（P〈0. 05）,while the level of prealbumin significantly increased（P〈0. 05）. The levels of blood /urine AMS in both groups did not change significantly（ P〉0. 05）. The differences in the level of TG,plasma viscosity,fibrinogen,platelet aggregation rate,erythrocyte sedimentation rate,levels of CRP,TNF-α,and prealbumin（ SIRS,APACHEⅡ,Ranson） score were found between the two group after the treatment（P〈0.05）. The incidence of respiratory failure,renal failure,ascites and pleural effusion in observation group was was significantly lower than that in the control group（P〈0. 05）. Conclusion Shuxuetong injection can improve the microcirculation and maintain pro-and anti-inflammatory cytokine balance,further to improve the QOL of patients with acute severe hyperlipidemic pancreatitis.

关 键 词：疏血通注射液 胰腺炎 高脂血症 

分 类 号：R589.2[医药卫生—内分泌] R657.51[医药卫生—内科学]