2013年3月江苏省禽流感职业暴露人群H5N1抗体水平及影响因素分析  

Antibody level of H5N1 avain influenza in occupationally exposed population in Jiangsu province in March,2013

作　　者：秦圆方[1] 许可[1] 祁贤[1] 邓斐[1] 余慧燕[1] 田华[1] 付建光[1] 李志锋[1] 王慎骄[1] 单军[1] 汤奋扬[1] 

机构地区：[1]江苏省疾病预防控制中心,卫生部肠道病原微生物重点实验室,江苏南京210009

出　　处：《南京医科大学学报（自然科学版）》2014年第6期839-843,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省医学重点人才培养项目(RC2011084);江苏省科技厅项目(BK20131450)

摘　　要：目的:调查H7N9流行初始江苏省职业暴露人群H5N1禽流感抗体水平及其影响因素。方法:分别使用香港株、广东株与安徽株抗原,用血清凝集抑制法(hemagglutination inhibition,HI)测定血清样本抗体滴度,计算几何平均滴度(geometric mean titer,GMT),统计分析影响抗体水平的因素。结果:检测职业暴露人群血清标本416份,性别与抗原株对职业暴露人群抗体滴度有显著影响。结论:江苏省职业暴露人群H5N1禽流感抗体滴度普遍较低。男性抗体滴度低于女性,广东株抗原与禽流感病毒现有流行株较为接近。Objective：To investigate the H5N1 avian influenza antibody level in occupational exposure population in Jiangsu province during the beginning of the influenza A（H7N9） outbreak.Methods：The antibody levels of Hong Kong,Guangdong and Anhui strain were detected using serum hemagglutination inhibition（HI） tests.The results were converted into geometric mean titer（GMT） and analyzed.Statistical analysis of the influencing factors of antibody levels was performed.Results：The difference was significant between antibody levels of different gender and antigen strains of all 416 serum samples tested.Conclusion：Our study showed that the antibody level of H5N1 avian influenza is low,and the levels of male are not as high as those of female.HI antibody level of Guangdong strain is closer to currently epidemic strains of avian flu in Jiangsu Province.

关 键 词：禽流感病毒 职业暴露人群 血清凝集抑制试验 流行特征 

分 类 号：R181.8[医药卫生—流行病学]