心源性猝死者窦房结组织SCN5A和ANK2表达及其法医学意义  

EXPRESSIONS OF SCN5A AND ANK2 IN SINO-ATRIAL NODAL TISSUE OF SUDDEN CARDIAC DEATH AND THEIR SIGNIFICANCE IN FORENSIC MEDICINE

作　　者：金利明[1] 杨彦华[1] 闫刚兴[2] 赵鹏[3] 张七一[4] 于建宪[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院病理科,山东青岛266071 [2]青岛市公安局技术处 [3]青岛大学医学院附属医院病理科 [4]青岛市市立医院心内科

出　　处：《青岛大学医学院学报》2014年第4期312-314,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市科研发展计划项目(13-1-4-129-jch)

摘　　要：目的探讨心源性猝死者窦房结组织SCN5A和ANK2表达及其法医学意义。方法收集尸检心脏标本26例,其中心源性猝死者12例(猝死组),排除心脏原因相关的异常死亡者14例(对照组)。应用免疫组化方法检测两组标本窦房结组织中SCN5A和ANK2编码的心肌钠离子通道(Nav1.5通道)和锚定蛋白B(ankyrin-B)的表达。结果猝死组窦房结组织中Nav1.5通道和ankyrin-B的表达均较对照组显著下降,差异有统计学意义(Z=-2.166、-2.505,P<0.05),但在猝死组中两者的表达无明显相关关系(r=-0.337,P>0.05)。结论窦房结组织SCN5A和ANK2表达的改变与心源性猝死的发生相关。Objective To investigate the expressions of SCN5Aand ANK2in sinus nodes of sudden cardiac death（SCD）and their significance in forensic medicine. Methods Twenty-six autopsy heart specimens were collected in this study.Of which,12were SCD,and 14were unnatural deaths of nothing to do with cardiac causes（control group）.The expressions of myocardial sodium channel protein（Nav1.5）and ankyrin-B which were encoded by SCN5Aand ANK2in sinus node were detected by immunohistochemical staining. Results The expressions of Nav1.5and ankyrin-B in the sinus node of the SCD were significantly lower than that of the control group（Z=-2.166,-2.505;P〈0.05）,and there was no significant correlation between the two expressions in the SCD group（r=-0.337,P〉0.05）. Conclusion The changes of the expressions of SCN5Aand ANK2in sinoatrial nodes are correlated with sudden cardiac death.

关 键 词：猝死 心脏 窦房结 钠通道 锚蛋白类 

分 类 号：R541.78[医药卫生—心血管疾病]