两种掩味剂对苦参水煎液的掩味作用考察  

Effects Investigation of Two Kinds of Taste Masking Agents to Decoction of Sophorae Flavescentis Radix

作　　者：康冰亚[1] 施钧瀚[1] 张璐[1] 张珊珊[2] 高晓洁[2] 刘瑞新[1] 李学林[1] 

机构地区：[1]河南中医学院第一附属医院药学部,郑州450000 [2]河南中医学院,郑州450008

出　　处：《中国实验方剂学杂志》2014年第15期4-7,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金青年基金项目(81001646)

摘　　要：目的：考察甜菊素及新橙皮苷二氢查尔酮对苦味药水提液的抑苦效果。方法：以苦参水煎液为研究载体，采用经典人群口尝评价方法，考察苦参水煎液加入不同质量分数掩味剂前后苦度值的变化情况。结果：甜菊素质量分数在0．075％～0．675％时，可使苦参水煎液苦度级别由Ⅳ逐步下降至Ⅲ，苦度值下降了0．58～1．26，下降比例14．0％～30．5％，至0．675％时抑苦效果最强，更高质量分数时抑苦效果无显著增加；新橙皮苷二氢查尔酮质量分数在0．003％～0．081％时，可使苦参水煎液的苦度级别由Ⅳ下降至Ⅲ，苦度值下降0．44～1．50，下降比例10．65％～36．32％；药液下降的苦度值与掩味剂质量分数的对数均成正比。结论：2种掩味剂对苦参水煎液的掩味效果不够理想，但均能在一定程度上降低苦参水煎液的苦度。Objective：To investigate inhibition effects of bitterness of steviosin and neohesperidin dihydrochalcone on decoction of traditional Chinese medicine with bitter taste.Method：Taking decoction of Sophorae Flavescentis Radix as a carrier,classic crowd tasting eveluation method was adopted to investigate changes of bitter value before and after adding different concentrations of taste masking agents into decoction.Result：When the mass fraction of stevioside was in the range of 0.075%-0.675%,bitter level of decoctions gradually droped by Ⅳ to Ⅲ,bitter value declined 0.58-1.26 with decline ratio of 14.0%-30.5%,inhibition effects of bitterness reached the strongest with the concentration of 0.675%,no significant improvement in inhibitory effects with higer concentration of taste masking agents,while the mass fraction of neohesperidosyl dihydrochalcone was in the range of 0.003 %-0.081%,bitter level of decoction gradually droped by Ⅳ to Ⅲ,bitter value declined 0.44-1.50 with decline ratio of 10.65%-36.32%.Logarithmic of the concentration of taste masking agents was proportional to bitter taste value drops of decoction.Conclusion：Effects of two kinds of taste masking agents was not ideal,but them both coulc reduce bitter to a certain extent of decoction of Sophorae Flavescentis Radix.

关 键 词：甜菊素 新橙皮苷二氢查儿酮 掩味剂 苦参水煎液 苦度值 口尝评价法 

分 类 号：R283.6[医药卫生—中药学]