紫硇砂醋制前后化学成分变化  

Variation of Chemical Constituents in Halitum Violaceum Before and After Processed by Vinegar

作　　者：季德[1,2] 毛春芹[1] 余玖霞[1] 李金慈[1] 陆兔林[1,2] 

机构地区：[1]南京中医药大学药学院,南京210023 [2]南京中医药大学江苏省中药炮制重点实验室,南京210023

出　　处：《中国实验方剂学杂志》2014年第15期44-48,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局公益性行业专项(200807039)

摘　　要：目的：比较紫硇砂醋制前后的化学成分变化,探讨其炮制减毒的物质基础.方法：采用硝酸银滴定法、紫外分光光度法、亚甲基蓝分光光度法、微波消解结合ICP-AES和指示剂变色等分析方法,比较紫硇砂醋制前后氯化钠、单质硫、硫化物、微量元素的含量变化并分析其炮制过程中释放的有害气体.结果：紫硇砂生品及醋制品中氯化钠含量均＞85％,醋制后氯化钠含量略增;生品、醋制品中单质硫质量分数分别为87.75 ～ 144.56,19.21 ～28.54μg·g-1;不同批次生品中硫化物质量分数0.045％ ～0.061％,醋制品中均未检测出硫化物;有害元素As,Cd,Cr,Pb等含量降低,炮制过程中逸出的臭味气体为硫化氢.结论：醋制提净了紫硇砂药材,去除了部分潜在的毒性成分,炮制后化学成分变化较大,为该药味炮制减毒机制的物质变化基础提供参考.Objective：To compare chemical constituents in Halitum Violaceum before and after processed by vinegarand explore its material basis of processing attenuated.Method：Silver nitrate titration method,ultraviolet spectrophotometric method,methylene blue spectrophotometric method,microwave digestioncombined ICP-AES method and indicator discoloration were adopted to compare contents of NaCl,sulphur,sulfide,trace elements before and after being processed by vinegar and odour gas escaped during processing course.Result：The content of NaCl were both higher than 85％ in crudeand vinegar processed Halitum Violaceum which was slightly higher after being processed; the mass fraction of sulphur in crudeand vinegar processed Halite Violaceous were 87.75-144.56 and 19.21-28.54 μg · g-1,respectively; the mass fraction of sulfide were between 0.045％-0.061％ in different batches of crudeprocessed Halitum Violaceum and no sulfide was detected in vinegar processed Halitum Violaceum.Harmful elements of As,Cd,Cr and Pb were reduced after being processed; odour gas escaped during processing coursewas hydrogen sulfide.Conclusion：Halitum Violaceumwas purified after being processed by vinegar,potential toxic ingredients were removed and chemical constituents were changed greatly.This study could provide a reference for material basis of processing attenuated mechanism of Halitum Violaceum.

关 键 词：紫硇砂 醋制工艺 化学成分变化 氯化钠 单质硫 硫化物 微量元素 有毒气体 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]