Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group  

作　　者：Shao-Hua Liu Wei Peng Yan-Yan Qu Dan Xu Hong-Yue Li Dun-Lun Song Hong-Xia Duan Xin-Ling Yang 

机构地区：[1]Department of Applied Chemistry,College of Science,China Agricultural University [2]Department of Entomology,College of Agriculture and Biotechnology,China Agricultural University

出　　处：《Chinese Chemical Letters》2014年第7期1017-1020,共4页中国化学快报（英文版）

基　　金：financially supported by the National Basic Research Program of China(No.2010CB126104)

摘　　要：A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR, 1H NMR, and HRMS （ESI）. Preliminary bioassay showed that some compounds, Sb and Sg, exhibited good activity against soybean aphids （Aphis glycines） at 100 mg L ^-1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR, 1H NMR, and HRMS （ESI）. Preliminary bioassay showed that some compounds, Sb and Sg, exhibited good activity against soybean aphids （Aphis glycines） at 100 mg L ^-1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.

关 键 词：Clothianidin analogues Hydrazide group Insecticidal activity Molecular docking 

分 类 号：TQ453.2[化学工程—农药化工]