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作 者:Hai-Yan Tian Peng-Wei Zhang Jun-Shan Liu Dong-Mei Zhang Xiao-Qi Zhang Ren-Wang Jiang Wen-Cai Ye
机构地区:[1]Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,Ji’nan University [2]School of Traditional Chinese Medicine,Southern Medical University [3]Southern Medical University [4]JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research,Ji’nan University
出 处:《Chinese Chemical Letters》2014年第7期1104-1106,共3页中国化学快报(英文版)
基 金:supported by National Natural Science Foundation of China(No.81102518);Postdoctoral Granted Financial Support(No.20110490915);the Guangdong High Level Talent Scheme(R.W.J.)
摘 要:Three new C-3 dehydrated bufadienolides were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated as 5β,12β-12,14-dihydroxy-11-oxobufa-3,20,22-trienolide (1), 5β,12β- 12,14-dihydroxy-11 -oxobufa-2,20,22-trienolide (2), and 5β,12β-12,14-dihydroxy-11 -oxobufa-2,20,22- trienolide (3) on the basis of extensive spectroscopic analysis, especially 1D NMR and 2D NMR data. In addition, all three compounds were tested for their cytotoxic activities against A549 and HepG2 cancer cell lines. Compounds 2 and 3 showed significant cytotoxicities with IC50 values less than 10 μmol/L on both cancer cells.Three new C-3 dehydrated bufadienolides were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated as 5β,12β-12,14-dihydroxy-11-oxobufa-3,20,22-trienolide (1), 5β,12β- 12,14-dihydroxy-11 -oxobufa-2,20,22-trienolide (2), and 5β,12β-12,14-dihydroxy-11 -oxobufa-2,20,22- trienolide (3) on the basis of extensive spectroscopic analysis, especially 1D NMR and 2D NMR data. In addition, all three compounds were tested for their cytotoxic activities against A549 and HepG2 cancer cell lines. Compounds 2 and 3 showed significant cytotoxicities with IC50 values less than 10 μmol/L on both cancer cells.
关 键 词:Toad venom Bufo bufo gargarizans 3-Dehydrated bufadienolide Cytotoxicity
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