怀山药多糖对大鼠胃溃疡的疗效及胃组织表皮生长因子水平的影响  

The effect of Dioscorea opposita polysaccharide in the treatment of rats with gastric ulcer and its influence on the level of EGF in gastric ulcer tissues

作　　者：罗鼎天[1] 陆其明[1] 杨志宏[1] 沈海燕[1] 

机构地区：[1]嘉兴市第二医院消化科,浙江省嘉兴314000

出　　处：《中国基层医药》2014年第15期2241-2243,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：基金项且：浙江省嘉兴市科技计划项目（2010AY1035）

摘　　要：目的：观察怀山药多糖对胃溃疡大鼠的治疗作用，研究怀山药多糖对胃溃疡大鼠胃组织表皮生长因子（EGF）水平的影响。方法将50只大鼠随机分为五组，分别为空白组（A组），模型组（B组），怀山药多糖组（C组），替普瑞酮组（D组）及怀山药多糖＋替普瑞酮组（E组）等。观察并比较各组胃溃疡的愈合情况，取胃组织检测并比较EGF水平。结果（1）C组的溃疡指数显著低于B组（P＜0．01）。（2）C组胃组织EGF水平显著高于A组（P＜0．05），与D组差异无统计学意义（P＞0．05）。结论怀山药多糖具有良好的胃黏膜保护作用，其机制可能与上调胃溃疡大鼠胃组织EGF水平有关。Objective To observe the therapeutic effect of Dioscorea opposita polysaccharide on gastric ulcer in rats,and to investigate the effects of Dioscorea opposita polysaccharide on level of epidermal growth factor （ EGF） in stomach tissues .Methods 50 rats were randomly divided into five groups [ A group （ normal control group ） , B group（model group）,C group（Dioscorea opposita polysaccharide group ）,D group（teprenone group）].The healing condition of gastric ulcer and EGF level were observed and compared .Results （1）The ulcer index of C group was obviously reduced compared with B group （P〈0.01）.（2）Between C group and A group,the significant difference existed in the level of EGF（P〈0.05）,while the difference was not statistically significant between C group and D group（P〉0.05）.Conclusion Dioscorea opposita polysaccharide has protective effects for gastric mucosa .The mechanism of protection may be related to promote synthesis of EGF .

关 键 词：甘薯 多糖类 胃溃疡 表皮生长因子 大鼠 

分 类 号：R285.5[医药卫生—中药学]