不同剂量静脉注射用人免疫球蛋白治疗川崎病疗效比较  

Comparison of the effect of different dose human immunoglobulin for intravenous injection in the treatment of Kawasaki disease

作　　者：李明[1] 严影[2] 

机构地区：[1]淮南市妇幼保健院儿内科,安徽省淮南232007 [2]淮南市妇幼保健院心电图室,安徽省淮南232007

出　　处：《中国基层医药》2014年第15期2268-2269,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：比较不同剂量静脉注射用人免疫球蛋白（ IVIG ）治疗川崎病（ KD ）的临床疗效。方法将55例KD患儿按收治时间不同分为两组，2002年1月至2006年2月收治的26例为A组，2006年10月至2013年6月收治的29例为B组，A组采用IVIG 0．4 g· kg^-1· d^-1，联用5 d；B组采用IVIG 2 g· kg^-1· d^-1，仅用1 d。比较两组热退时间和冠脉损害（CAL）发生率。结果 A组平均热退时间为（38±4）h，B组平均热退时间为（34±3）h，两组差异有统计学意义（t＝4．15，P＜0．05）；A组CAL发生率为6．9％，高于B组的6.1％，但差异无统计学意义（χ2＝0．253，P＞0．05）。结论 IVIG 2 g· kg^-1· d^-1，仅用1 d，优于0．4 g· kg^-1· d^-1，联用5 d。Objective To compare the effect of different dose human immunoglobulin for intravenous injec-tion（ IVIG） in the treatment of Kawasaki disease （ KD） .Methods According to different time ,55 children with KD were divided into two groups.26 patients between January 2002 and February 2006 were selected as group A,while 29 patients between October 2006 and June 2013 were selected as group B .Patients in group A were given IVIG 0.4 g· kg^-1· d^-1 ×5d,while group B was given IVIG 2 g· kg-1 · d-1 ×1d.Then,the time of fever-reducing and CAL of the two groups were compared .Results The time of fever-reducing in group A was （38 ±4） h,that in group B was （34 ±3）h,there was significant difference between the two groups （t=4.15,P〈0.05）.The incidence rate of CAL in group A was 6.9%,which was higher than 6.1%in B group,but the difference was not statistically signifi-cant（χ2 =0.253,P〉0.05）.Conclusion The treatment of KD with IVIG 2 g· kg^-1· d^-1 ×1d is more superior than IVIG 0.4 g· kg^-1· d^-1 ×5d.

关 键 词：粘膜皮肤淋巴结综合征 免疫球蛋白类 静脉内 

分 类 号：R725.4[医药卫生—儿科]