山精胶囊对实验性高脂血症大鼠血脂的影响  

Effect of Shanjing Capsule on Blood Lipid of Experimental Hyperlipidemia Rats

作　　者：董培良[1] 于栋华[1] 包顺茹[1] 刘树民[1] 

机构地区：[1]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150040

出　　处：《中医药信息》2014年第4期90-92,共3页Information on Traditional Chinese Medicine

摘　　要：目的:观察山精胶囊对实验性高脂血症大鼠血脂水平的影响。方法:采用高脂饲料建立大鼠高脂血症模型,将高脂血症大鼠按照血清TC,TG的水平随机分成空白组,模型组,山精胶囊高、中、低剂量组和心安胶囊组,给药10天后检测各组大鼠血脂水平和脂质过氧化水平。结果:与模型组相比,山精胶囊可以显著降低TC、TG、LDL-C、ApoB和MDA的含量,升高HDL-C、ApoA1和NO的含量,增强SOD、GSH-Px的活性(P<0.05)。结论:山精胶囊可通过增强抗氧化酶活性,调整实验性高脂血症大鼠血脂的作用。Objective：To observe the effect of Shanjing capsule on blood lipid of experimental hyperlipidemia rats.Methods：Use high fat feed to establish rats hyperlipidemia models .According to serum TC and TG lev-els, hyperlipidemia rats were randomly divided into blank group , model group, Shanjing capsule high, medi-um and low dose groups and Xin＇an capsule group .Then we detected blood lipid levels and lipid peroxidation level indicators in each group after 10 days administration .Results： Compared with model group , Shanjing capsule could significantly decrease TC , TG, LDL-C, ApoB and MDA and increase HDL -C, ApoA1 and the content of NO and enhance the activities of SOD , GSH-Px （ P〈0 .05 ） .Conclusion： Shanjing capsule has an obviously adjusted effect on blood lipid of experimental hyperlipidemia rats by enhancing antioxidant enzyme activity .

关 键 词：高脂血症 山精胶囊 血脂水平 

分 类 号：R285.5[医药卫生—中药学]