细菌性肺炎患儿血清降钙素原水平变化及临床意义  

The changes of procalcitonin level in children with bacterial pneumonia and its clinical significance

作　　者：黄玉柱[1] 杨惠泉[1] 高璐璐[1] 张开俊[1] 袁长亮[1] 高奎武[1] 

机构地区：[1]蚌埠市第一人民医院儿内科,安徽省蚌埠233000

出　　处：《中国基层医药》2014年第11期1631-1632,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 观察细菌性肺炎患儿血清降钙素原（PCT）水平变化及临床意义.方法 31例肺炎患儿,在抗生素治疗前后均检测PCT、hs-CRP、WBC水平,以观察其变化情况.结果 31例患儿治疗前PCT均升高.患儿治愈后,PCT正常28例,但其中WBC升高者仍有10例（35.7％）,hs-CRP升高者仍有4例（14.3％）.另外3例PCT分别由入院时的5.69 ng/mL、1.25 ng/mL及0.83 ng/mL,分别下降为0.51 ng/mL、0.55 ng/mL及0.52 ng/mL,此3例WBC及hs-CRP升高各1例,但是WBC由13.1×10^9/L下降为12.1×10^9/L、hs-CRP由20.92 mg/L下降为7.38 mg/L.结论 细菌性肺炎患儿血清急性时相指标中PCT敏感性最高,可指导抗生素的使用.Objective To observe the changes and clinical significance of procalcitonin（PCT） level in children with bacterial pneumonia.Methods The levels of PCT,hs-CRP and WBC were detected in 31 pneumonia children pre and post antibiotic treatment,and the changes were observed.Results The PCT levels of the 31 patients were all increased before treatment.After cured,PCT level of 28 cases returned to normal.But in the 28 normal cases,WBC level increased in 10 cases（35.7%）,and hs-CRP level elevated in 4 cases（14.3%）.In the other 3 cases,the PCT levels decreased from 5.69ng/mL,1.25ng/mL and 0.83ng/mL at admission to 0.51ng/mL,0.55ng/mL and 0.52ng/mL,respectively.And in these 3 cases,there was one case with the levels of WBC and hs-CRP respectively ascended,in which WBC level descended from 13.1 × 10^9/L to 12.1 × 10^9/L and hs-CRP level reduced from 20.92mg/L to 7.38mg/L.Conclusion The sensitivity of the index PCT is the highest at the accurate time phase of bacterial pneumonia,which can guide the reasonable use of antibiotics.

关 键 词：降钙素原 肺炎 细菌性 儿童 

分 类 号：R725.6[医药卫生—儿科]