不同e抗原状态的慢性乙肝及相关肝病的临床特点研究  

Research on clinical characteristics of chronic hepatitis B and related liver diseases with different HBeAg status

作　　者：江宗群[1] 李锐锋[1] 陈世厚[1] 段军[1] 

机构地区：[1]解放军第477医院感染科,湖北襄阳441003

出　　处：《临床军医杂志》2014年第7期685-687,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨不同e抗原状态即HBeAg(-)和HBeAg(+)两类慢性乙型病毒性肝炎(CHB)及相关肝病的临床特点。方法对505例初次住院的CHB患者进行回顾性调查,分析HBeAg(-)和HBeAg(+)乙肝患者的性别、年龄、肝硬化及肝癌检出率、HBV DNA定量、肝组织病理学的组间差异。结果 HBeAg(-)组CHB患者年龄明显大于HBeAg(+)组,其肝硬化、肝癌发生率高,肝组织纤维化程度较HBeAg(+)组重;HBeAg(+)组CHB患者HBV DNA载量总体上高于HBeAg(-)组。结论 HBeAg(-)组CHB患者的预后差,临床工作者要重视HBeAg(-)组CHB患者的治疗。Objective To investigate the clinical characteristics of two different kinds （ i. e. HBeAg-negative or HBeAg-positive） of chronic hepatitis B （CHB） and related liver diseases. Methods A total of 505 patients with CHB treated in our department for the first time were retrospectively investigated. They were divided into two groups： HBeAg-negative group and HBeAg-positive group. Age, sex, detected rates of liver cirrhosis and cancer, HBV DNA and liver histological change were analyzed. Results The patients were significantly older in the HBeAg-negative group than in the HBeAg-positive group. Compared with those in the HBeAg- positive group, the patients in the HBeAg-negative group had higher incidences of liver cirrhosis and cancer, and more advanced hepatic fibrosis. The HBV DNA load of the HBeAg-positive group was higher than that of the HBeAg-negative group. Conclusion The prognosis of the CI-IB patients with negative HbeAg is worse than that of those with positive HBeAg. So they should be paid more attention to in clinical practice.

关 键 词：慢性乙型肝炎 肝硬化 肝肿瘤 乙型肝炎病毒脱氧核糖核酸 组织学 乙型肝炎E抗原 

分 类 号：R512.62[医药卫生—内科学]