手性脯酰胺催化剂的合成及其在不对称Michael加成反应中的应用  

Chiral Preserved Amide Synthesis of Catalyst and Its Application in Asymmetric Michael Addition Reaction

作　　者：许良明[1] 许海霞[1] 郁杨洁 嘉雪晶 雷丽枝 李春梅[1] 张富仁[1] 

机构地区：[1]绍兴文理学院化学化工学院,浙江绍兴312000

出　　处：《广东化工》2014年第13期36-36,20,共2页Guangdong Chemical Industry

基　　金：浙江省科技厅项目(2010R50014-17);2012年度绍兴市大学生科技创新项目

摘　　要：本论文主要研究了L-脯氨酸衍生的手性脯酰胺催化剂的设计、合成及其在不对称Michael加成反应中的应用。我们以硝基烯和环己酮为底物,考察了催化剂1和2在不对称Michael加成反应的催化活性和立体选择性。结果表明,以二氯甲烷为溶剂,以化合物2为催化剂,以三氟乙酸为辅助试剂,于室温反应12小时,加成产物的收率可达81%,立体选择性为71%。This paper mainly studied the L - proline derivatives chiral preserved amide catalyst in the design, synthesis and its application in asymmetric Michael addition reaction. We nitrocellulose and cyclohexanone as substrates, examines the catalyst 1 and 2 in the asymmetric Michael addition reaction of catalytic activity and stereoselectivity. The results showed that the dichloromethane as solvent, the catalyst for compound 2, with trifluoroacetic acid as auxiliary reagent, 12 hours at room temperature reaction, addition product yield can reach 81%, stereoselectivity was 71%.

关 键 词：L-脯氨酸 硝基烯 不对称MICHAEL加成反应 

分 类 号：O643.36[理学—物理化学]