高敏肌钙蛋白T在慢性心力衰竭患者中的表达及对近期预后的影响  

Hypersensitive cardiac troponin T level and its prognostic value in patients with chronic heart failure

作　　者：罗立[1] 黄怡[1] 翦林昊 

机构地区：[1]湖南省常德市第一人民医院心血管内科,415003

出　　处：《中华临床医师杂志（电子版）》2014年第14期72-75,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨慢性心力衰竭患者高敏肌钙蛋白T(hs-cTnT)的表达水平与心力衰竭严重程度、炎症反应的关系,评价其对心力衰竭近期预后的预测价值。方法选取慢性心力衰竭患者共110例,按NYHA心功能分级分为心功能Ⅱ级组37例,Ⅲ级组40例,Ⅳ级组33例,检测hs-cTnT、血清超敏C反应蛋白(hs-CRP)、氨基末端脑钠肽前体水平(NT-proBNP)及超声心动图。出院患者90 d随访,记录主要心脏不良事件(MACE)包括因心力衰竭加重再入院或死亡。结果 (1)hs-cTnT表达水平随心功能分级增加而增高(P<0.05);(2)hs-cTnT与hs-CRP呈正相关(r=0.822,P<0.05);(3)hs-cTnT阳性组MACE的发生率高于hs-cTnT阴性组(33.8%vs.10.7%,P<0.05)。结论 (1)hs-cTnT的表达水平与心力衰竭严重程度相关,且与炎症反应存在相关性;(2)hs-cTnT阳性患者近期预后差。Objective To evaluate hypersensitive cardiac troponin T 0as-cTnT） level in patients with chronic heart failure （CHF） and its prognostic value. Methods 110 patients with CHF were selected and divided in to class Ⅱ （n=37）, Class Ⅲ（n=40） and Class Ⅳ（n=33）, according to New York Heart Association（NYI-IA） cardiac function classification, hs-cTnT, hypersensitive C-reactive protein （hs-CRP）, NT-proBNP and echocardiography were detected. Through the 90 days＇ follow-up for the discharged patients, major adverse cardiac events （MACE） including readmissions due to the worsening of heart failure or the death were recorded. Results （1）hs-cTnT increased with heart function grade increased（P〈0.05）. （2）hs-cTnT was positively correlated with hs-CRP （r=0.822, P〈0.05）. （3）The incidence of MACE in hs-cTnT positive group was higher than the negative group（33.8% vs. 10.7%, P〈0.05）. Conclusion （1）Expression of hs-cTnT was correlated with the severity of heart failure, and was associated with inflammation. （2）hs-cTnT positive patients have poor prognosis.

关 键 词：心力衰竭 肌钙蛋白T C反应蛋白质 

分 类 号：R541.6[医药卫生—心血管疾病]