凝集素样氧化型低密度脂蛋白受体水平对冠状动脉支架置入术后再狭窄的预测价值  

Predictive value of lectin-like ox-LDL receptor-1 level to restenosis after intracoronary stent implantation

作　　者：闫杰[1] 赵红[1] 刁增利[1] 苏鹏宇[1] 王志军[1] 李海涛[1] 

机构地区：[1]河北联合大学附属医院心内科,唐山063000

出　　处：《中国循证心血管医学杂志》2014年第3期322-324,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(冠心病)患者冠状动脉支架置入术后血清凝集素样氧化型低密度脂蛋白受体-1(Lox-1)变化趋势及与支架内再狭窄(ISR)的关系。方法连续入选经皮冠状动脉介入治疗并置入冠状动脉支架的冠心病患者128例。分别于术前和术后24h、1周、2周、1月、3月、6月时采集外周静脉血,测定血清Lox-1水平。所有患者术后6月常规复查冠状动脉造影,以支架内径狭窄≥50%为再狭窄,分为再狭窄组(n=24)和无再狭窄组(n=104),并分析两组患者血清Lox-1水平变化趋势及差别。结果术后24h两组患者血清Lox-1水平较术前明显增加,有统计学差异(P<0.05);冠状动脉无再狭窄组患者术后1周血清Lox-1水平有下降趋势,2周时恢复至术前水平,术后1个月、3个月、6个月血清Lox-1水平与术前比较无统计学差异(P>0.05)。冠状动脉再狭窄组患者血清Lox-1水平术后两周、术后1个月、3个月、6个月时血清Lox-1水平呈持续性升高,与无再狭窄组相比,差异有统计学意义(P<0.05)。结论冠状动脉支架置入患者血清Lox-1水平在两周时基本恢复至术前水平,未恢复至术前水平且持续升高者发生支架内再狭窄危险性高。Objective To discuss the relationship between the change tendency of serum lectin-like ox-LDL receptor-1 （Lox-1） and in-stent restenosis （ISR） in patients with coronary heart disease （CHD） after intracoronary stent implantation. Methods The patients （n=128） with percutaneous coronary intervention （PCI） and intracoronary stent implantation were chosen, and the samples of peripheral venous blood were collected from them respectively before the surgery and after the surgery for 24 h, 1 w, 2 w, 1 m, 3 m and 6 m for detecting the level of serum Lox-1. All patients were given routine reexamination of coronary angiography （CAG）, and then they were divided into restenosis group （n=24） and non-restenosis group （n=104） taken ISR≥50%as restenosis criterion. The change tendency and difference of Lox-1 were analyzed in 2 groups. Results The level of Lox-1 increased significantly （P〈0.05） in 2 groups after the surgery for 24 h. In non-restenosis group, Lox-1 level had decreasing tendency after 1 w, recovered to the level before surgery after 2 w, and had no statistical difference （P〉0.05） after 1 m, 3 m and 6 m. In restenosis group, Lox-1 level increased continuously after surgery for 2 w, 1 m, 3 m and 6 m compared with non-restenosis group （P〈0.05）. Conclusion The level of serum Lox will recover to the level before surgery in the patients with intracoronary stent implantation. If Lox-1 level dose not recover and increases continuously, the risk of ISR is higher.

关 键 词：凝集素样氧化型低密度脂蛋白受体-1 经皮冠状动脉介入术 支架 再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]