芪苈强心胶囊联合卡维地洛对心力衰竭患者核因子-κB及诱导型一氧化氮合酶水平的影响  

Influence of Qili Qiangxin Capsules Combined with Carvedilol on the Levels of Blood NF-κB and iNOS in Congestive Heart Failure

作　　者：陈玲[1] 徐鑫媛 汶医宁[1] 刘建荣 

机构地区：[1]陕西中医学院第一附属医院

出　　处：《中西医结合心脑血管病杂志》2014年第7期787-789,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察芪苈强心胶囊联合卡维地洛对慢性心力衰竭患者核因子-κB(NF-κB)及诱导型一氧化氮合酶(iNOS)水平的影响。方法 120例慢性心力衰竭患者随机分为常规组、卡维地洛组、芪苈强心胶囊联合卡维地洛组(联合组),各40例。采用荧光定量PCR法和酶联免疫分析方法分别测定各组治疗前及治疗12周后血液NF-κB和iNOS的水平,测定左室射血分数,并进行6min步行试验。结果治疗12周后,卡维地洛组、芪苈强心胶囊联合卡维地洛组血液NF-κB和iNOS水平均较常规组明显下降(P<0.01),6min步行距离显著增加(P<0.05),左室射血分数明显提高(P<0.05);卡维地洛组与联合组相比较,血液NF-κB和iNOS水平下降(P<0.05),而6min步行距离、左室射血分数无统计学意义。结论芪苈强心胶囊联合卡维地洛治疗慢性心力衰竭可提高患者运动耐力,并改善心脏功能,推测芪苈强心胶囊联合卡维地洛可能通过抑患者炎性因子的表达而改善心功能。Objective To observe the influence of carvedilol combined with Qili Qiangxin capsules（QQC）on the levels of blood nuclear factor kappa B （NF κB）,inducible nitric oxide synthase （iNOS）in patients with early congestive heart failure（CHF）. Methods One hundred and twenty patients with early CHF were randomly divided into routine treatment group,carvedilol group,and carvedilol combined with QQC treatment groups,and 40 cases were included in each group.After medication for 12 weeks,the blood levels of iNOS and NF κB were detected with enzyme linked immunosorbent assay and fluorescent quantitation PCR,respectively. The left ventricular ej ection fraction （LVEF）and walking distance in 6 minutes were detected at the same time.Results After 1 2 weeks drug therapy,the blood levels of NF κB and iNOS were decreased significantly （P〈0.01）,and walking distance in 6 minutes and LVEF were increased（P〈0.05）in carvedilol group and carvedilol combined with QQC groups compared with that in routine treat-ment group.The blood levels of NF κB and iNOS were decreased （P〈0.05）in carvedilol group compared with carvedilol combined with QQC group,while there were no significantly differences of walking distance in 6 minutes and LVEF between the two groups. Conclusion QQC combined with carvedilol could improve the exercise tolerance and improve cardiac function of early CHF patients and it might due to its inhibiting effects on the expression of inflammation factors.

关 键 词：慢性心力衰竭 卡维地洛 芪苈强心胶囊 核因子ΚB 诱导型一氧化氮合酶 

分 类 号：R541.6[医药卫生—心血管疾病]