2型糖尿病持续皮下胰岛素输注治疗起始剂量与体质指数相关性研究  

Correlation between body mass index and insulin dose in type 2 diabetic patients with continuous subcutaneous insulin infusion

作　　者：梁翠格[1] 董庆玉[1] 杜文华[1] 刘晓萌[1] 李文侠[1] 王月丽[1] 公倩[1] 潘振宇[1] 高冠起[1] 

机构地区：[1]山东省临沂市人民医院,276003

出　　处：《实用医学杂志》2014年第15期2408-2410,共3页The Journal of Practical Medicine

基　　金：山东省2012年科技发展计划项目(政策引导类)(编号:2012YD18019)

摘　　要：目的：探讨2型糖尿病（T2DM）患者持续皮下胰岛素输注治疗（CSII）起始胰岛素剂量与体重指数（BMI）的关系。方法：300例住院T2DM患者，按BMI分为正常体重组（BMI〈23kg／m2），超重组（BMI23—25kg／m2）和肥胖组（BMI≥25kg／m2）。经过CSII治疗血糖达标后，比较各组胰岛素剂量和临床参数差异。分析胰岛素剂量的可能影响因素。结果：3组比较日胰岛素剂量无差异。超重、肥胖组日单位体重胰岛素剂量显著低于正常体重组。日胰岛素剂量与HbAlc、病程、体重、HOMA．islet（CP．DM）呈正相关。日单位体重胰岛素剂量与病程、HOMA-islet（CP．DM）呈正相关，与体重、BMI呈负相关。结论：不同BMI的T2DM患者存在血糖水平、胰岛素分泌功能及胰岛素抵抗程度等差异。在设定T2DM患者CSII起始胰岛素剂量时，可先按BMI分层．再根据体重估算。Objective To investigate the correlation between BMI and insulin dose in diabetic patients after short-term continuous subcutaneous insulin infusion （CSII）. Methods Three hundred patients with type 2 diabetes mellitus （T2DM） were enrolled and randomized into the normal weight （BMI 〈 23 kg/m2） group, overweight （BMI 23 ~ 25 kg/m2） group and obesity （BMI ≥ 25 kg/m2） group. The metabolic and anthropometric parameters of each group were compared and the related factors which may influence insulin dose were analyzed. Results The insulin dose per weight in the overweight group or in the obesity groups was significantly lower than that in the normal weight group. Weight and BMI were negatively correlated with the insulin dose per weigh. Conclusions Differences of glycemia level, β-cell function and insulin resistance exist in Chinese type 2 diabetes patients with different BMI. The stratification of BMI should be considered before estimating the insulin dose by body weight in CSII therapy.

关 键 词：糖尿病 2型 体质指数 胰岛素剂量 持续皮下胰岛素注射 

分 类 号：R587.1[医药卫生—内分泌]