替罗非班对急诊PCI术后患者血清可溶性CD40配体、缺氧诱导因子α、诱导性一氧化氮合成酶的影响  

Impacts of tirofiban on plasma levels of sCD40L, HIF-1α, and iNOS

作　　者：李慧娟[1] 徐会圃[1] 

机构地区：[1]滨州医学院附属医院心内科,256603

出　　处：《实用医学杂志》2014年第15期2481-2483,共3页The Journal of Practical Medicine

基　　金：山东省高等学校科技计划项目(编号:J11LF98)

摘　　要：目的：观察替罗非班对行急诊PCI术患者血清可溶性CD40配体（sCD40L）、缺氧诱导因子（HIF-1α）浓度及诱导性一氧化氮合成酶（iNOS）活性的影响。方法：80例接受直接PCI术的急性ST段抬高型心肌梗死患者，随机分为替罗非班组和对照组，每组40例：替罗非班组：术中球囊扩张后支架植入前冠脉内注入10μg／kg替罗非班，术后以维持量0．15μg／（kg·min）持续微量泵泵入24～36h；对照组：球囊扩张术后直接行支架植入术。测定两组患者PCI术前、术后12hsCD40L、HIF-1α、iNOS的水平。结果：术后12h血清sCD40L、HIF-1α、iNOS水平高于PCI术前（P〈0．05）。与对照组比较，替罗非班组血清sCD40L、HIF-1α、iNOS水平明显降低（P〈0．05）。结论：本研究初步提示了替罗非班不但具有抗血小板聚集作用，而且还能抗炎和保护血管内皮。Objective To observe the impacts of tirofiban on plasma levels of sCD40L and HIF-1α, and iNOS activity in patients undergoing emergency PCI. Methods A total of 80 patients with acute STEMI received primary PCI were randomly divided into a tirofiban group and a control group. The tirofiban group received tirofiban of 10 μg/kg, followed by an infusion of tirofiban of 0.15 μg/（kg-min） for 24 ~ 36 hours; while the control group directly received stent implantation after balloon angioplasty. Plasma levels of sCD40L, HIF-1α, and iNOS were detected in baselines and 12 hours after the procedrue. Results 12 hours after the procedure, serum levels of sCD40L, HIF-1α, and iNOS were higher than the baseline levels （P 〈 0.05）. As compared with the control group, levels of sCD40L, HIF-1α, and iNOS were significantly lower （P 〈 0.05）. Conclusions This study preliminarily sugguests tirofiban has a role in anti-inflammation and protection of vascular endothelium besides anti-platelet effects.

关 键 词：心肌梗死 介入治疗 替罗非班 SCD40L HIF-1Α INOS 

分 类 号：R542.22[医药卫生—心血管疾病]