丙泊酚注射液与依托咪酯注射液的配伍稳定性考察  

Compatible Stability of Propofol Injection and Etomidate Injection

作　　者：廖勇[1] 游艳[1] 

机构地区：[1]三峡大学仁和医院药学部,湖北宜昌443001

出　　处：《中国药房》2014年第30期2826-2828,共3页China Pharmacy

基　　金：湖北省宜昌市科技局重大项目(No.A13301-40)

摘　　要：目的:考察丙泊酚注射液与依托咪酯注射液的配伍稳定性。方法:取丙泊酚注射液和依托咪酯注射液一定量按20 mg∶2mg的比例混合,分装成5份后分别在37℃恒温水浴箱中放置0、4、8、12、24 h,采用核磁共振波谱(NMR)法检测二者混合后是否生成新的物质,使用二甲基亚砜(DMSO)-d6溶剂溶解后分别进行H1-NMR的图像采集。结果:通过与标准品谱图对比及对不同水浴时间下混合样品间谱图峰面积积分可知,丙泊酚、依托咪酯二者混合后在上述条件下表现出良好的化学稳定性。结论:所建方法简便、快速、准确;丙泊酚注射液与依托咪酯注射液混合后无化学性质的变化,配伍稳定,可在临床联合应用。OBJECTIVE： To investigate the compatible stability of Propofol injection and Etomidate injection. METHODS： Pro- pofol injection and Etomidate injection were mixed according to 20 mg ：2 mg and divided into 5 parts with water bath for 0 h, 4 h, 8 h, 12 h or 24 h at 37 ℃. New substance was detected by NMR after mixing. Then the solutions had been dissolved by DMSO-d6 and H1-NMR image captured. RESULTS： The comparison of H1-NMR and spectrum peak area of samples with water bath for different time showed good chemical stability of samples after mixing under above conditions. CONCLUSIONS ： The meth- od is simple, rapid and accurate for detecting the stability of Propofol injection and Etomidate injection and the stability of chemi- cal property after mixing, and the results show they can be combined in the clinic.

关 键 词：丙泊酚注射液 依托咪酯注射液 核磁共振波谱法 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学]