替加环素不良反应回顾性分析  

Retrospective analysis of adverse drug reactions induced by tigecycline

作　　者：李昱霖[1] 梁志欣[1] 王彬[2] 朱曼[3] 骆海伦 陈良安[1] 佘丹阳[1] 

机构地区：[1]解放军总医院呼吸科,北京100853 [2]解放军总医院胸外科,北京100853 [3]解放军总医院药品保障中心,北京100853

出　　处：《中国药物应用与监测》2014年第2期111-114,共4页Chinese Journal of Drug Application and Monitoring

基　　金：全军医学科技"十二五"科研项目(BWS11J057)

摘　　要：目的:提高对替加环素不良反应的认识,为临床合理用药提供参考。方法:通过检索文献,对替加环素不良反应病例中患者一般情况、原患疾病、不良反应类型、不良反应发生时间、治疗方法及转归等进行分析,同时报道1例使用替加环素后引起低血糖反应患者的诊疗过程,并结合文献进行分析。结果:共检索出10例替加环素不良反应的个案报道,其中胰腺炎8例,腹泻1例,凝血功能异常1例。本文报道的1例78岁男性患者诊断为重症肺炎、慢性阻塞性肺疾病、肺间质纤维化,机械通气过程中,痰培养多次为多重耐药鲍曼不动杆菌,在使用替加环素静脉滴注后出现顽固性低血糖。结论:应用替加环素时,应高度警惕其不良反应的发生,确保安全用药。Objective： To pay more attention to the adverse drug reactions （ADRs） induced by tigecycline and providereferences for rational use of drugs. Methods： By reviewing the literatures, the ADRs induced by tigecyline were analyzed in respectof general data, primary disease of the patients, types of ADRs, occurrence time, therapeutic method, prognosis, etc. Meanwhile,a case of tigecycline-induced hypoglycemia was reported. Results： Ten ADRs cases induced by tigecycline were collected. Eightcases of them were pancreatitis, one case of diarrhea, one case of coagulation disorder. A 78-year-old male patient was diagnosed assevere pneumonia, chronic obstructive pulmonary disease, and pulmonary interstitial fibrosis developing persistent hypoglycemiaafter intravenous infusion of tigecycline. During the mechanical ventilation, the result of sputum culture was multi-drugs resistantAcinetobacter Bauman. Conclusion： More attention should be paid to adverse events induced by tigecycline to ensure the safety ofdrug use in clinic.

关 键 词：替加环素 药品不良反应 低血糖 

分 类 号：R97[医药卫生—药品]