产褥感染患者血清C反应蛋白水平变化及意义分析  

Serum C-reactive protein level change in patients with puerperal infection and its significance

作　　者：刘敏[1] 周路贞 黄洁红[1] 

机构地区：[1]广东省惠州市第二妇幼保健院,广东惠州516008

出　　处：《中国处方药》2014年第4期13-15,共3页Journal of China Prescription Drug

摘　　要：目的探讨C反应蛋白在产后产褥感染患者血清中的表达水平及其在产褥感染诊断中的临床意义。方法随机选取2012年10月～2013年8月孕妇3 800例,其中采用阴道分娩方式1 710例(A组),采用剖宫产方式分娩2 090例(B组)。监测两组产前1 d及产后7 d内白细胞计数(WBC计数)、C反应蛋白以及48 h体温变化。对两组不同分娩方式产后产褥感染率进行对比分析,并对产褥感染病例及无感染病例产后1、3、5、7d内的C反应蛋白水平变化加以监测。结果采用阴道分娩方式以及剖宫产方式分娩产后WBC计数和C反应蛋白的变化水平显著高于产前水平;阴道方式分娩产后产褥感染率为1.42%(24例),而剖宫产方式分娩产后产褥感染率高达6.96%(136例),剖宫产方式分娩产后产褥感染率高于阴道方式分娩,差异具有统计学意义(P<0.05);与无产褥感染病例比较,产褥感染病例在产后1 d C反应蛋白水平开始迅速升高,第3天达到高峰,5～7 d后开始降低,但都高于正常水平。结论剖宫产分娩可增加孕妇产后产褥感染率,在产褥感染患者血清C反应蛋白水平迅速升高,对孕妇产后产褥感染的早期发现及诊断有重要意义。Objective To investigate the expression level of C-reactive protein （CRP） in the serum of patients with puerperal infection and its clinical significance in the diagnosis of puerperal infection. Methods 3 800 pregnant women in our hospital were randomly selected. According to the mode of delivery, 3 800 pregnant women were divided into two groups： one was vaginal delivery group （ 1710 cases） , and the other was cesarean section group （2090 cases） . The patients＇ temperature in 48 hours were monitored. The White blood cell count （WBC） and CRP level in the serum of all the patients were detected at one day before delivery, the first, third, fifth and seventh after delivery. Then compared the indices of the two groups and figured out the chang of CRP level in the patients with （or without） puerperal infection. Results The WBC and CRP level of Postnatal patients in two groups were significantly higher prenatal levels. Vaginal delivery group postpartum puerperal infection rate was 1.42% （24 cases）, and cesarean section group postpartum puerperal infection rate was 6.96% （ 136 cases）, puerperal infection rate of cesarean section group was significantly higher than the vaginal delivery group （P 〈 0.05 ）. Compared with patients without infection, Serum C-reactive protein level of patients ＇ with puerperal infection began to rise rapidly at the first day after delivery, and had been highest at the third day, and then began to decrease. Conclusion The cesarean delivery can increase maternal postpartum puerperal infection, serum C-reactive protein level in patients with puerperal infection increase rapidly, which is important in the early postpartum and diagnosis with puerperal infection in pregnant women.

关 键 词：产褥感染 C反应蛋白 剖宫产 阴道分娩 

分 类 号：R714.62[医药卫生—妇产科学]