慢性肾功能不全患者血液胆汁酸浓度增高的病理机制研究  

MECHANISM ON THE INCREASE OF BLOOD BILE ACID CONCENTRATION IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY

作　　者：张巍峨[1] 

机构地区：[1]大连大学,辽宁省大连市116622

出　　处：《中国煤炭工业医学杂志》2014年第8期1250-1251,共2页Chinese Journal of Coal Industry Medicine

摘　　要：目的探讨慢性肾功能不全患者血液胆汁酸浓度变化的病理机制。方法分析观察组和对照组血液胆固醇、胆汁酸、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)浓度变化情况并进行统计学分析。结果观察组各测定指标显著高于对照组。结论细胞炎性分子通过抑制胆汁酸的合成和抑制胆盐转运蛋白基因表达从而抑制肝细胞对血液中胆汁酸的重吸收和肝细胞对胆汁酸的排泌,使胆汁酸的肠肝循环减弱而血液胆汁酸浓度增高。Objective To explore the pathologic mechanism of the blood bile acid concentration increase in patients with chronic renal insufficiency. Methods The change of the concentrations of blood cholesterol, bile acid, TNF- α, and IL - 6 were analyzed in the patient group and the control group and then put the data to statistic analysis. Results Every index of the patient group was much higher than those of the con- trol group. Conclusion By inhibiting the formation of bile acid and the expression of bile salt transporters, inflammation cytokines inhibit the reabsorption and excretion of bile acid in liver cell, it results in a circula- tion reduce of bile acid in liver and a concentration increase of bile acid in Mood.

关 键 词：胆汁酸 肿瘤坏死因子 白细胞介素-6 慢性肾功能不全 

分 类 号：R692[医药卫生—泌尿科学]